{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:31:39Z","timestamp":1777422699069,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study evaluated the effects of uvulopalatopharyngoplasty (UPPP) on serum leptin levels and endothelial function in patients with obstructive sleep apnea syndrome (OSAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifteen healthy subjects and 35 patients with moderate to severe OSAS who desired UPPP were prospectively enrolled. The serum levels of leptin and nitric oxide derivative (NOx) from their peripheral blood samples were measured by enzyme-linked immunosorbent assay. All subjects participated in sleep studies, which were repeated 3 months after UPPP in the patients with OSAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Before UPPP, the patients with OSAS had a higher serum level of leptin and a lower NOx level than did the control subjects. The serum leptin levels in the 17 of the 35 patients with OSAS who were surgical responders decreased from 24.2 \u00b1 6.1 ng\/mL before operation to 15.9 \u00b1 6.0 ng\/mL after operation. The serum NOx levels in these 17 patients increased from 18.5 \u00b1 7.5 \u00b5mol\/L before operation to 27.3 \u00b1 8.2 \u00b5mol\/L after operation. In the 18 patients who were unresponsive to surgery, the serum leptin and NOx levels remained impaired after the UPPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Successful treatment of OSAS with UPPP leads to the normalization of serum leptin and NOx levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489414521385","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T05:28:58Z","timestamp":1393478938000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Uvulopalatopharyngoplasty on Leptin and Endothelial Function in Sleep Apnea"],"prefix":"10.1177","volume":"123","author":[{"given":"Ching-Chi","family":"Lin","sequence":"first","affiliation":[{"name":"Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research (Lin, Liaw), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology (Wang, Lee), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Sleep Center (Lin, Chiu), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College (Lin), Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Piao","family":"Wang","sequence":"additional","affiliation":[{"name":"Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research (Lin, Liaw), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology (Wang, Lee), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Sleep Center (Lin, Chiu), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College (Lin), Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research (Lin, Liaw), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology (Wang, Lee), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Sleep Center (Lin, Chiu), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College (Lin), Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwu-Fang","family":"Liaw","sequence":"additional","affiliation":[{"name":"Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research (Lin, Liaw), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology (Wang, Lee), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Sleep Center (Lin, Chiu), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College (Lin), Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Hsin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research (Lin, Liaw), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology (Wang, Lee), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Sleep Center (Lin, Chiu), Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College (Lin), Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"bibr1-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0261"},{"key":"bibr2-0003489414521385","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509002586"},{"key":"bibr3-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431310"},{"key":"bibr4-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.5.2103001"},{"key":"bibr5-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105124"},{"key":"bibr6-0003489414521385","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.1035"},{"key":"bibr7-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.5.538"},{"key":"bibr8-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.3.716"},{"key":"bibr9-0003489414521385","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881450"},{"key":"bibr10-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.10.017"},{"key":"bibr11-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-008-9131-5"},{"key":"bibr12-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2005.00562.x"},{"key":"bibr13-0003489414521385","doi-asserted-by":"publisher","DOI":"10.2174\/138161207783018635"},{"key":"bibr14-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-06-0392"},{"key":"bibr15-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.003"},{"key":"bibr16-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.2.156"},{"key":"bibr17-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.155"},{"key":"bibr18-0003489414521385","unstructured":"Iber C, Ancoli-Israel S, Chesson AL, Quan SF. The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specifications. Westchester, Ill: American Academy of Sleep Medicine, 2007."},{"key":"bibr19-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.221"},{"key":"bibr20-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803726"},{"key":"bibr21-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1002\/clc.21010"},{"key":"bibr22-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1223OC"},{"key":"bibr23-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-009-0246-6"},{"key":"bibr24-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095272.67948.17"},{"key":"bibr25-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.1.H234"},{"key":"bibr26-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1159\/000088358"},{"key":"bibr27-0003489414521385","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0154"}],"updated-by":[{"DOI":"10.1177\/0003489417692649","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000}}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489414521385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489414521385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489414521385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:21:14Z","timestamp":1777375274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489414521385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/0003489414521385"],"URL":"https:\/\/doi.org\/10.1177\/0003489414521385","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}