{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:26:47Z","timestamp":1777426007385,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to determine the duration of use, presentation, and management of angiotensin converting enzyme (ACE) inhibitor-related angioedema patients at an urban academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighty-eight patients who presented with ACE inhibitor-related angioedema between January 1, 2012, and December 31, 2012, were identified. They presented anywhere from 1 day to 20 years after starting an ACE inhibitor. About half the patients (50.7%) presented after taking an ACE inhibitor for at least 1 year. Fifty-five patients were female (62.5%). Twenty-eight patients (31.8%) had an airway intervention with 27 intubated and 1 requiring cricothyroidotomy. Six patients were intubated after more than 1 flexible laryngoscopy. The percentage of patients with involvement of the face, lips, tongue, floor of mouth, soft palate\/uvula, and larynx were 12.5%, 60.2%, 39.7%, 6.8%, 17.0%, and 29.5%, respectively. Sixty-eight percent of patients with laryngeal edema were intubated. The majority of patients were treated with a corticosteroid and H\n                      <jats:sub>1<\/jats:sub>\n                      and H\n                      <jats:sub>2<\/jats:sub>\n                      receptor antagonists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Angioedema can occur at any time after starting ACE inhibitor use, with nearly half occurring after 1 year of use. Laryngeal involvement occurred in a minority of patients, but most of these patients were felt to require airway protection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489414543069","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T22:44:58Z","timestamp":1406241898000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Angiotensin Converting Enzyme Inhibitor-Related Angioedema"],"prefix":"10.1177","volume":"124","author":[{"given":"Norman J.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,24]]},"reference":[{"key":"bibr1-0003489414543069","first-page":"461","volume":"66","author":"Bickett DP","year":"2002","journal-title":"Am Fam Physician"},{"key":"bibr2-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2013.05.052"},{"key":"bibr3-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60594-7"},{"key":"bibr4-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.08.007"},{"key":"bibr5-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22349"},{"key":"bibr6-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.08.012"},{"key":"bibr7-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.14.1637"},{"key":"bibr8-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.110270"},{"key":"bibr9-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328363c137"},{"key":"bibr10-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2006.05689.x"},{"key":"bibr11-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011901208"},{"key":"bibr12-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833d3acb"},{"key":"bibr13-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.03.029"},{"key":"bibr14-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19294"},{"key":"bibr15-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.096552"},{"key":"bibr16-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1177\/0897190012465990"},{"key":"bibr17-0003489414543069","first-page":"CD008165","volume":"5","author":"Patterson SM","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr18-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70182-8"},{"key":"bibr19-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21277"},{"key":"bibr20-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.09.010"},{"key":"bibr21-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0323-y"},{"key":"bibr22-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.10.002"},{"key":"bibr23-0003489414543069","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.031"},{"key":"bibr24-0003489414543069","unstructured":"US Department of Health and Human Services, Centers for Disease Control and Prevention. 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