{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:28:34Z","timestamp":1777426114340,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The purpose of our article was to explore the effect of ethosomes containing 5-fluorouracil (5-FU) with different sizes on laryngotracheal stenosis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The physical characteristics of ethosomes containing 5-FU were investigated, including size, shape, and entrapment percentage. The effect of ethosomes containing 5-FU was evaluated on the airway stenosis rabbit model. The formation of fibrous\/scar tissue was investigated by hematoxylin and eosin (HE) staining, and the permeation depth was observed under fluorescence microscope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean sizes of 5-FU ethosomes extruded by D = 50 nm and D = 100 nm pore were 60 \u00b1 10 nm and 110 \u00b1 13 nm, respectively. The 5-FU entrapment percentage of ethosomes was determined to be 15% (D = 60 \u00b1 10 nm) and 32% (D = 110 \u00b1 13 nm). After being treated by ethosomes containing 5-FU (D = 60 \u00b1 10 nm), the fibroblast and collagenous fiber distributed sparsely in the deep scar tissue. The permeation capability of ethosomes containing 5-FU (D = 60 nm) was significantly better than ethosomes (D = 110 nm). Besides, the 5-FU ethosomes resulted in less stenosis than 5-FU only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Topical administration of 5-FU ethosomes may be a novel candidate therapy for laryngotracheal stenosis treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415570928","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T21:55:07Z","timestamp":1423778107000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["A Novel Therapy for Laryngotracheal Stenosis"],"prefix":"10.1177","volume":"124","author":[{"given":"Jian","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Shanghai 3rd People\u2019s Hospital School of Medicine, Shanghai Jiao-tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai 3rd People\u2019s Hospital School of Medicine, Shanghai Jiao-tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai 3rd People\u2019s Hospital School of Medicine, Shanghai Jiao-tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafei","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai 3rd People\u2019s Hospital School of Medicine, Shanghai Jiao-tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xizhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai 3rd 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