{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:15:29Z","timestamp":1784693729249,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>It has been suggested that remodeling of the otic capsule is highly suppressed by the action of anti-resorptive signals emanating from structures of the inner ear space. Labyrinthitis ossificans (LO) is a severe complication to bacterial meningitis and is characterized by destruction of inner ear structures by the formation of new bone. The aim of this study was to explore the impact of LO on bone remodeling of the otic capsule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>In 11 human temporal bones with extensive LO and 10 control specimens, the degree of bone remodeling was explored indirectly by estimating the viability of osteocytes in perilabyrinthine bone and the mastoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The viability of osteocytes was significantly lower in the perilabyrinthine bone compared to the mastoid in both groups. However, the loss of perilabyrinthine osteocytes was the same in the 2 groups, and the presence of cartilage remnants appeared to be the same.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study indicates that the factors affecting bone remodeling of the otic capsule and the degeneration of osteocytes are not altered by wholesale destruction of inner ear soft tissue and its replacement by bone. Therefore, alternative mechanisms may be implicated in the suppression of capsular bone remodeling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415573960","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T23:38:18Z","timestamp":1426030698000},"page":"649-654","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Labyrinthitis Ossificans"],"prefix":"10.1177","volume":"124","author":[{"given":"Sune Land","family":"Bloch","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael John","family":"McKenna","sequence":"additional","affiliation":[{"name":"Massachusetts Eye & Ear Infirmary, Harvard University Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Adams","sequence":"additional","affiliation":[{"name":"Massachusetts Eye & Ear Infirmary, Harvard University Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"bibr1-0003489415573960","first-page":"375","volume":"17","author":"Merchant SN","year":"1996","journal-title":"Am J Otol"},{"key":"bibr2-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600303"},{"key":"bibr3-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300303"},{"key":"bibr4-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400214"},{"key":"bibr5-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900106"},{"key":"bibr6-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150702.28451.35"},{"key":"bibr7-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000191466.09210.9a"},{"key":"bibr8-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.09.007"},{"key":"bibr9-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01581"},{"key":"bibr10-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607290200"},{"key":"bibr11-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1177\/000348944805700303"},{"key":"bibr12-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22492"},{"key":"bibr13-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.02.006"},{"key":"bibr14-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000218"},{"key":"bibr15-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-438X(04)95535-1"},{"key":"bibr16-0003489415573960","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903253603"},{"key":"bibr17-0003489415573960","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1971.00770070375010"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415573960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489415573960","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415573960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:43Z","timestamp":1777375843000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489415573960"}},"subtitle":["On the Mechanism of Perilabyrinthine Bone Remodeling"],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1177\/0003489415573960"],"URL":"https:\/\/doi.org\/10.1177\/0003489415573960","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]}}}