{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:51:05Z","timestamp":1784749865858,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      per dose, administered orally, twice daily at approximately 12-hour intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415583330","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T20:46:02Z","timestamp":1429735562000},"page":"820-823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus"],"prefix":"10.1177","volume":"124","author":[{"given":"Sule","family":"Yesil","sequence":"first","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhun","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmet G\u00fclsah","family":"Tanyildiz","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel Akpinar","family":"Tekgunduz","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Onur","family":"Candir","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Toprak","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurses","family":"Sahin","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"bibr1-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.11.024"},{"key":"bibr2-0003489415583330","first-page":"1825","volume-title":"Gray\u2019s Anatomy","volume":"2011","author":"Standring S."},{"key":"bibr3-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-010-0065-x"},{"key":"bibr4-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23124"},{"key":"bibr5-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.05.037"},{"key":"bibr6-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.03.044"},{"key":"bibr7-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90062-8"},{"key":"bibr8-0003489415583330","first-page":"253","volume":"26","author":"Fageeh N","year":"1997","journal-title":"J Otolaryngol"},{"key":"bibr9-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(99)80042-1"},{"key":"bibr10-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.6"},{"key":"bibr11-0003489415583330","doi-asserted-by":"publisher","DOI":"10.4103\/0975-5950.85862"},{"key":"bibr12-0003489415583330","first-page":"475","volume-title":"Oral and Maxillofacial Pathology","volume":"2002","author":"Neville BW","edition":"2"},{"key":"bibr13-0003489415583330","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110963"},{"key":"bibr14-0003489415583330","unstructured":"Marx RE, Stern D. 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