{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:18:24Z","timestamp":1793092704586,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Analyze demographic data collected over a 25-year experience of 718 patients with spasmodic dysphonia (SD) who have been treated with botulinum toxin-A (BoNT-A) and compare our data with previously published studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven hundred eighteen patients with SD were treated with 6621 BoNT-A injections at Mayo Clinic Arizona between 1989 and 2014. All patients were treated by the same physician team. Background demographic data for each patient were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 718 patients, 557 patients were female (77.6%). Six hundred sixty of 718 (91.8%) patients had adductor SD (AdSD), and 58 of 718 (8.1%) patients had abductor SD (AbSD). Average age of onset was 51 years. Of 718 patients, 378 (52.6%) had vocal tremor (VT); VT was present in 54.4% of AdSD patients and 32.1% of AbSD patients. Thirty-seven of 718 (5.2%) patients had other dystonias, including cervical dystonia (2.3%), blepharospasm (1.4%), limb dystonia (1.1%), and oromandibular dystonia (0.3%). A positive family history of SD was present in only 6 of 718 patients (0.8%) and of other dystonias in 11 of 718 patients (1.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Spasmodic dysphonia is a chronic and potentially disabling focal laryngeal dystonia. The Mayo Clinic Arizona SD experience compares to prior reports and reveals a female preponderance, onset in middle age, infrequent hereditary pattern, high co-occurrence of VT, and low co-occurrence of other dystonias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415588557","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T22:36:04Z","timestamp":1432938964000},"page":"859-863","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["The Mayo Clinic Arizona Spasmodic Dysphonia Experience"],"prefix":"10.1177","volume":"124","author":[{"given":"Alpen B.","family":"Patel","sequence":"first","affiliation":[{"name":"Mayo Clinic, Department of Otolaryngology\u2013Head and Neck Surgery, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Bansberg","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Otolaryngology\u2013Head and Neck Surgery, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Neurology, Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Lott","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Otolaryngology\u2013Head and Neck Surgery, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Crujido","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Otolaryngology\u2013Head and Neck Surgery, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"bibr1-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1191\/0269215506cr931oa"},{"key":"bibr2-0003489415588557","volume-title":"Clinical Voice Disorders: An Interdisciplinary Approach","author":"Aronson A","year":"1990"},{"key":"bibr3-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9924(81)90037-X"},{"key":"bibr4-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000201"},{"key":"bibr5-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000503"},{"key":"bibr6-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000708"},{"key":"bibr7-0003489415588557","first-page":"38","volume-title":"The MIT Encyclopedia of Communication Disorders","volume":"2004","author":"Ludlow CL"},{"key":"bibr8-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22426"},{"key":"bibr9-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000179174.32345.41"},{"key":"bibr10-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00004"},{"key":"bibr11-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31090-9"},{"key":"bibr12-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03047.x"},{"key":"bibr13-0003489415588557","first-page":"104","volume":"22","author":"Tanner K","year":"2012","journal-title":"Am Speech Lang Hear Assoc"},{"key":"bibr14-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(84)80015-0"},{"key":"bibr15-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.9.1416"},{"key":"bibr16-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(03)00020-1"},{"key":"bibr17-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21872"},{"key":"bibr18-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199810000-00003"},{"key":"bibr19-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.5.688"},{"key":"bibr20-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22168"},{"key":"bibr21-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.03.007"},{"key":"bibr22-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32832aef6f"},{"key":"bibr23-0003489415588557","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25567"}],"container-title":["Annals of Otology, Rhinology &amp; 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