{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:21Z","timestamp":1777426341429,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Transsphenoidal surgery (TSS) harbors a potential for hypopituitarism, cerebrospinal fluid (CSF) leaks, and other complications. We utilized the Nationwide Inpatient Sample Database (NIS) to compare inpatient complication rates between Cushing\u2019s disease (CD) and non-Cushing\u2019s disease (NCD) patients undergoing TSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Inpatient hospitalization data for 960 CD and 12\u2005110 NCD patients who underwent TSS between 2002 and 2010 were accessed. Demographic information, outcomes, and complication rates were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with CD had a female predilection (81.7%) and were younger (40.5 \u00b1 14.4 years) than NCD patients (47.8% female; 52.1 \u00b1 16.3 years) ( P &lt; .001). Length of stay and total charges did not differ between groups. Patients with CD had significantly greater postoperative diabetes insipidus rates (14.0% vs 9.6%, P &lt; .001) and urinary\/renal complications (1.7% vs 0.9%, P = .027). After adjusting for possible confounders, the relationship between urinary\/renal complications and CD status strengthened. There was no difference in rates of CSF leak and iatrogenic pituitary disorders overall.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>No differences were noted in the rate of early CSF leaks between postoperative TSS CD and NCD patients. Postoperative diabetes insipidus did not significantly differ between groups after adjusting for confounders. Only odds of urinary\/renal complications in CD patients was significant after adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415595424","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T20:00:09Z","timestamp":1436990409000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Inpatient Complications After Transsphenoidal Surgery in Cushing\u2019s Versus Non-Cushing\u2019s Disease Patients"],"prefix":"10.1177","volume":"125","author":[{"given":"Peter F.","family":"Svider","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milap D.","family":"Raikundalia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan J.","family":"Pines","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Folbe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA"},{"name":"Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA"},{"name":"Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"bibr1-0003489415595424","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.FOCUS12125"},{"key":"bibr2-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02380.x"},{"key":"bibr3-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01261.x"},{"key":"bibr4-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0342-z"},{"key":"bibr5-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21216"},{"key":"bibr6-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0368-2"},{"key":"bibr7-0003489415595424","doi-asserted-by":"publisher","DOI":"10.3171\/2012.2.JNS111837"},{"key":"bibr8-0003489415595424","doi-asserted-by":"publisher","DOI":"10.3171\/2011.1.FOCUS10317"},{"key":"bibr9-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817e2c43"},{"key":"bibr10-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3815-0"},{"key":"bibr11-0003489415595424","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.23.3.9"},{"key":"bibr12-0003489415595424","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2011.06.016"},{"key":"bibr13-0003489415595424","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3378"},{"key":"bibr14-0003489415595424","unstructured":"Overview of the National (Nationwide) Inpatient Sample (NIS). http:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp. 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