{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:55:02Z","timestamp":1784426102591,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,19]],"date-time":"2015-07-19T00:00:00Z","timestamp":1437264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Autologous adipose injection (AAI) is a recognized method for vocal fold augmentation. The study\u2019s purpose is to explore short- and long-term outcomes of AAI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective chart review of 43 patients undergoing AAI was performed; patient perception of outcome, Voice Handicap Index (VHI), maximum phonatory time (MPT), and disposition were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Over 5 years, 43 AAI patients had documented postoperative follow-up (25 paralysis, 8 paresis, 9 bowing\/presbylarynges, and 5 scar\/sulci). Mean follow-up was 32 weeks. There was gradual patient loss to follow-up. Thirty-nine of 40 (98%) had patient-reported improvement at 6 weeks, 28 of 34 (82%) had improvement at 2 to 6 months, with 10 of 12 (83%) sustaining their improvement for &gt;1 year. Significant improvement in mean VHI was observed at 4 to 6 weeks (mean reduction, 26; P &lt; .0001) and 2 to 6 months (mean reduction, 23; P &lt; .0001). Improvement in mean MPT was observed at 4 to 6 weeks (mean increase, 8 s; P &lt; .0001), 2 to 6 months (6 s; P = .007), and &gt;1 year (4 s; P = .03). Eight patients went on to medialization laryngoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AAI successfully augments vocal folds in short-term outcomes with some gradual decrease in effectiveness. Although patient attrition limited conclusions, objective long-term benefit may occur in &gt;50% of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415595427","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T19:59:04Z","timestamp":1437422344000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Augmentation Autologous Adipose Injections in the Larynx"],"prefix":"10.1177","volume":"125","author":[{"given":"Michael S.","family":"Benninger","sequence":"first","affiliation":[{"name":"Cleveland Clinic Department of Otolaryngology, Head and Neck Surgery, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Hanick","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Nowacki","sequence":"additional","affiliation":[{"name":"Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,19]]},"reference":[{"key":"bibr1-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100419"},{"key":"bibr2-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199603\/04)18:2<174::AID-HED10>3.0.CO;2-F"},{"key":"bibr3-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr4-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"bibr5-0003489415595427","first-page":"93","volume":"18","author":"Bruennings W","year":"1911","journal-title":"Ver Deutsch Laryng"},{"key":"bibr6-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199702000-00008"},{"key":"bibr7-0003489415595427","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.177"},{"key":"bibr8-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199105000-00003"},{"key":"bibr9-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00019"},{"key":"bibr10-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181735634"},{"key":"bibr11-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199205000-00005"},{"key":"bibr12-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02824.x"},{"key":"bibr13-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.016"},{"key":"bibr14-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.42"},{"key":"bibr15-0003489415595427","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00017"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415595427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489415595427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415595427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:55Z","timestamp":1777375855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489415595427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,19]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1177\/0003489415595427"],"URL":"https:\/\/doi.org\/10.1177\/0003489415595427","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,19]]}}}