{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:29Z","timestamp":1777426349808,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy of the novel method for the targeted delivery of Mn\n                      <jats:sup>++<\/jats:sup>\n                      to the inner ear and monitor calcium metabolism activity in the inner ear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Dynamic signal changes of Mn\n                      <jats:sup>++<\/jats:sup>\n                      in the rat inner ear were followed using T\n                      <jats:sub>1<\/jats:sub>\n                      -weighted magnetic resonance imaging (MRI) after administration of 2.5 \u00b5l MnCl\n                      <jats:sub>2<\/jats:sub>\n                      (500 mM) to the medial wall of the middle ear cavity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mn\n                      <jats:sup>++<\/jats:sup>\n                      passed through both the oval and round windows and distributed in the perilymphatic compartments, where it formed bright sharp lines along the fluid-cellular borders 12 minutes post administration and entered the endolymph sufficiently after 45 minutes. After 6 hours, the distribution of Mn\n                      <jats:sup>++<\/jats:sup>\n                      shifted from a fluid-dominant pattern to a cell-dominant pattern. Mn\n                      <jats:sup>++<\/jats:sup>\n                      concentrated in the area of the basilar membrane, periphery process, and soma of the spiral ganglion on day 2; became more distinguishable on day 4; declined on day 8; and remained detectable for 16 days post administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The novel targeted delivery method efficiently introduced Mn\n                      <jats:sup>++<\/jats:sup>\n                      into the inner ear. The dynamic distribution pattern of Mn\n                      <jats:sup>++<\/jats:sup>\n                      in the inner ear shown by MRI indicates that this method can be used to monitor calcium metabolism activity in the inner ear.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415597916","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T19:59:57Z","timestamp":1438286397000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Calcium Metabolism Profile in Rat Inner Ear Indicated by MRI After Tympanic Medial Wall Administration of Manganese Chloride"],"prefix":"10.1177","volume":"125","author":[{"given":"Jing","family":"Zou","sequence":"first","affiliation":[{"name":"Hearing and Balance Research Unit, Field of Oto-laryngology, School of Medicine, University of Tampere, Tampere, Finland"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Center for Otolaryngology-Head & Neck Surgery of Chinese PLA, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilmari","family":"Pyykk\u00f6","sequence":"additional","affiliation":[{"name":"Hearing and Balance Research Unit, Field of Oto-laryngology, School of Medicine, University of Tampere, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"bibr1-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018475"},{"key":"bibr2-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.159bx.x"},{"key":"bibr3-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03664.1990"},{"key":"bibr4-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.1153"},{"key":"bibr5-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91520-3"},{"key":"bibr6-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90040-2"},{"key":"bibr7-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464650"},{"key":"bibr8-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/BF00464655"},{"key":"bibr9-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050049"},{"key":"bibr10-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/s007950000012"},{"key":"bibr11-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/BF02905990"},{"key":"bibr12-0003489415597916","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125130"},{"key":"bibr13-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00230-5"},{"key":"bibr14-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400515"},{"issue":"3","key":"bibr15-0003489415597916","first-page":"E512","volume":"276","author":"Dryselius S","year":"1999","journal-title":"Am J Physiol"},{"key":"bibr16-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21645"},{"key":"bibr17-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.10.003"},{"key":"bibr18-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.003"},{"key":"bibr19-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1038\/nn1477"},{"key":"bibr20-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014260"},{"key":"bibr21-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.04.022"},{"key":"bibr22-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.08.014"},{"key":"bibr23-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3249"},{"key":"bibr24-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-6"},{"key":"bibr25-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1159\/000329760"},{"key":"bibr26-0003489415597916","first-page":"5","volume":"2","author":"Zou J","year":"2015","journal-title":"Edorium J Otolaryngol"},{"key":"bibr27-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.065"},{"key":"bibr28-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.086"},{"key":"bibr29-0003489415597916","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2008.1.3.117"},{"key":"bibr30-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-10-1"},{"key":"bibr31-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/BF00183496"},{"key":"bibr32-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/BF00634775"},{"key":"bibr33-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-009-0043-9"},{"key":"bibr34-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2188-06.2006"},{"key":"bibr35-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1159\/000115431"},{"key":"bibr36-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950121105"},{"key":"bibr37-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01143-2"},{"key":"bibr38-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1102-e263"},{"key":"bibr39-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:27:2:225"},{"key":"bibr40-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000233864.32183.81"},{"key":"bibr41-0003489415597916","doi-asserted-by":"publisher","DOI":"10.1159\/000084024"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415597916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489415597916","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415597916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:56Z","timestamp":1777375856000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489415597916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1177\/0003489415597916"],"URL":"https:\/\/doi.org\/10.1177\/0003489415597916","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]}}}