{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:10Z","timestamp":1777426330024,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify trends in treatment and survival for patients with stage I glottic cancer and glottic carcinoma in situ (CIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The 18-registry SEER data were analyzed for CIS and stage I glottic cancer. Treatment variables and observed and relative survival were assessed separately for stage I and glottic CIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 14\u2005025 cases of stage I glottic cancer identified from 1988 to 2012, radiation was the most common treatment for all eras. An increase in surgical treatment occurred with a decline in combination therapy. There were 3169 cases of glottic CIS, with surgery the most common initial treatment but with radiotherapy increasing across the years. Relative survival was similar for treatment type and era of diagnosis. Among the 3738 patients with glottic CIS, 5.4% went on to develop invasive glottic carcinoma of any stage, with invasive cancer more common in patients treated by surgery alone compared to radiation or surgery with radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Despite changes in treatment modalities for CIS and stage I glottic cancer, there have not been significant changes in survival for CIS, with slightly improved survival for treatment with surgery alone. Patients treated with surgery alone had an increased rate of subsequent invasive cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415611908","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:24:32Z","timestamp":1445300672000},"page":"311-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012"],"prefix":"10.1177","volume":"125","author":[{"given":"Sobia F.","family":"Khaja","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry T.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin A.","family":"Pagedar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"bibr1-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.014"},{"key":"bibr2-0003489415611908","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1237"},{"key":"bibr3-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23504"},{"key":"bibr4-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90095-7"},{"issue":"6","key":"bibr5-0003489415611908","first-page":"603","volume":"38","author":"Higgins KM","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"bibr6-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"bibr7-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28608"},{"key":"bibr8-0003489415611908","unstructured":"National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch. Surveillance, Epidemiology, and End Results (SEER) Program Research Data (1973-2011). http:\/\/www.seer.cancer.gov. Accessed June 1, 2015."},{"key":"bibr9-0003489415611908","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.09.005"},{"key":"bibr10-0003489415611908","unstructured":"National Center for Health Statistics. Expected survival, 1970-2010 by individual year, released 2015. http:\/\/seer.cancer.gov\/expsurvival\/. Accessed June 1, 2015."},{"key":"bibr11-0003489415611908","unstructured":"Cho H, Howlader N, Mariotto AB, Cronin KA. Estimating relative survival for cancer patients from the SEER Program using expected rates based on Ederer I versus Ederer II method. Surveillance Research Program, NCI, Technical Report No. 2011-01. http:\/\/surveillance.cancer.gov\/reports\/tech2011.01.pdf. Accessed June 1, 2015."},{"key":"bibr12-0003489415611908","unstructured":"Dickman P. Estimating and modelling relative survival using SAS. http:\/\/biostat3.net\/download\/sas\/relative_survival_using_sas.pdf. Accessed June 1, 2015."},{"key":"bibr13-0003489415611908","unstructured":"American College of Surgeons. National Cancer Database Commission on Cancer. Benchmark reports. www.facs.org\/cancer\/ncdb. 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