{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:25Z","timestamp":1777426345180,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Conventional wisdom is that the overwhelming majority of glottic cancer patients have a smoking history. However, in recent years observations suggested that an increasing number of glottic cancer patients had never been smokers. Therefore, an investigation was done examining the incidence of having a smoking history in a recent cohort of glottic cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Retrospective review of 100 patients with glottic cancer to determine those reporting never having smoked.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-one of 100 did not have a smoking history. Clinical observations of those cases revealed that the disease morphology tended to be exophytic, papillary, and very vascular, often resembling recurrent respiratory papillomatosis (RRP). Remarkably, 2 of 31 were initially treated elsewhere assuming they had RRP and underwent 5 cidofovir injections. Both presented with advanced cancer, and the disease growth markedly accelerated coincident with the injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Observations herein provide new insights that glottic cancer may be an evolving disease in which smoking is less exclusive, not unlike HPV-induced pharynx cancer. Similar to RRP, the angiogenic papillary disease morphology is well suited for voice-preserving angiolytic KTP laser treatment. Given the resemblance of some glottic cancers to RRP, great care should be taken when using cidofovir for papillary glottic neoplasms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489415619177","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T21:49:09Z","timestamp":1448574549000},"page":"452-456","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Glottic Cancer"],"prefix":"10.1177","volume":"125","author":[{"given":"Steven M.","family":"Zeitels","sequence":"first","affiliation":[{"name":"Department of Surgery, Harvard Medical School, and Division of Laryngeal Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"bibr1-0003489415619177","volume-title":"Diseases and Injuries of the Larynx and Trachea","author":"Ryland F","year":"1841"},{"key":"bibr2-0003489415619177","volume-title":"Laryngeal Phthisis, Chronic Laryngitis and Diseases of the Voice","author":"Trousseau A","year":"1841"},{"key":"bibr3-0003489415619177","volume-title":"Histoire des Polyps du Larynx","author":"Ehrmann CH","year":"1850"},{"key":"bibr4-0003489415619177","volume-title":"On the Surgical Treatment of Polypi of the Larynx, and Oedema of the Glottic","author":"Green H","year":"1852"},{"key":"bibr5-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-188510000-00019"},{"key":"bibr6-0003489415619177","volume-title":"The Fatal Illness of Frederick the Noble","author":"Mackenzie M","year":"1888"},{"key":"bibr7-0003489415619177","first-page":"52","volume":"17","author":"Castro J","year":"1989","journal-title":"Time"},{"key":"bibr8-0003489415619177","first-page":"182","volume":"44","author":"Jackson C","year":"1922","journal-title":"Transactions of the American Laryngological Association"},{"key":"bibr9-0003489415619177","volume-title":"Cancer of the Larynx","author":"Jackson C","year":"1939"},{"key":"bibr10-0003489415619177","unstructured":"American Academy of Otolaryngology Head and Neck Surgery. Voice box \u201claryngeal\u201d cancer. http:\/\/www.entnet.org\/content\/voice-box-laryngeal-cancer. Accessed November 16, 2015."},{"key":"bibr11-0003489415619177","volume-title":"Presented at the annual meeting of the American Broncho-Esophagological Association","author":"Rosow D","year":"2004"},{"key":"bibr12-0003489415619177","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000348940811700101","volume":"117","author":"Zeitels SM","year":"2008","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"bibr13-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414538936"},{"key":"bibr14-0003489415619177","first-page":"1","volume":"201","author":"Zeitels SM","year":"2009","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"bibr15-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112001001"},{"key":"bibr16-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200302"},{"key":"bibr17-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700802"},{"key":"bibr18-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021944123914"},{"key":"bibr19-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm233"},{"key":"bibr20-0003489415619177","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2086-4"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415619177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489415619177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489415619177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:31:05Z","timestamp":1777375865000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489415619177"}},"subtitle":["A Metamorphosing Disease"],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1177\/0003489415619177"],"URL":"https:\/\/doi.org\/10.1177\/0003489415619177","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}