{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:34:06Z","timestamp":1777426446838,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To analyze the area under the curve (AUC) from 24-hour pharyngeal pH probes and evaluate this parameter as a predictor of disease severity for laryngopharyngeal reflux.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eighty patients met inclusion criteria of a completed 24-hour pharyngeal pH probe and Reflux Symptom Index (RSI) questionnaire. The AUC was calculated below a pH threshold of 5.5 using the trapezoidal rule. The RSI and RYAN scores were correlated with AUC values, and nonparametric tests were used for comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median AUC value was 18\u2009007 pH-seconds with an interquartile range (IQR) of 63\u2009156, the median RSI score was 21 (IQR = 16), and the median RYAN score was 15.3 (IQR = 78). There was a Spearman\u2019s correlation of .36 between the RSI scores and AUC values ( P = .001) and a moderate correlation between AUC values and RYAN scores (0.58, P &lt; .001). An insignificant correlation of .19 between RYAN scores and RSI scores was observed ( P = .09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The AUC may be a useful objective value in establishing the diagnosis of laryngopharyngeal reflux. Prospective studies with larger patient populations are necessary to validate these findings and determine standardized thresholds for symptomatic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489416687308","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T11:05:39Z","timestamp":1483787139000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Analyzing the Area Under the Curve of Pharyngeal pH Probes in the Diagnosis of Reflux Disease"],"prefix":"10.1177","volume":"126","author":[{"given":"Joel W.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Sykes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pavelonis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hema","family":"Pappu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Garnett","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"issue":"4","key":"bibr1-0003489416687308","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"Koufman JA.","year":"1991","journal-title":"Laryngoscope"},{"key":"bibr2-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00936.x"},{"key":"bibr3-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000043372.98660.82"},{"key":"bibr4-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.12.006"},{"key":"bibr5-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20282"},{"key":"bibr6-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790222"},{"key":"bibr7-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81193-6"},{"key":"bibr8-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"bibr9-0003489416687308","volume-title":"Manual of Pharmacologic Calculations: With Computer Programs","author":"Tallarida RJ","year":"1987"},{"key":"bibr10-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0915-6"},{"key":"bibr11-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"bibr12-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800561211"},{"key":"bibr13-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197610000-00009"},{"key":"bibr14-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90196-R"},{"key":"bibr15-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00693.x"},{"key":"bibr16-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40626.x"},{"key":"bibr17-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2007.12.005"},{"key":"bibr18-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800302"},{"key":"bibr19-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01505.x"},{"key":"bibr20-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90899-5"},{"key":"bibr21-0003489416687308","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.08.025"}],"container-title":["Annals of Otology, Rhinology &amp; 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