{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:12Z","timestamp":1792949412147,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI49235"],"award-info":[{"award-number":["R01 AI49235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gromo Sinus Center"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The study aimed to evaluate symptoms described by patients with chronic rhinosinusitis with polypoid changes\/nasal polyps and their correlation with computed tomography (CT), nasal endoscopy, and intranasal biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Prospective multicenter study symptom data from postsurgical adult chronic rhinosinusitis study participants with recurrent disease refractory to medical therapy were analyzed in comparison with objective data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using logistic regression analysis, participant-rated 16-question surveys from 258 participants were assessed for correlation with nasal endoscopy scores, CT percentage of sinus occlusion, and intranasal biomarkers of fungal antigens (Alternaria and Aspergillus), eosinophilic inflammation (eosinophil-derived neurotoxin [EDN] and major basic protein [MBP]), and inflammatory cytokines (interleukins 5 and 13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Study participant assessments revealed increased CT occlusion in participants presenting with greater inability to smell ( P &lt; .019). Mucosal inflammation identified on nasal endoscopy was positively correlated with congestion ( P &lt; .028), runny nose ( P &lt; .002), and ear pain ( P &lt; .007). Elevated EDN was positively correlated in patients with bothersome congestion ( P &lt; .031) and runny nose ( P &lt; .011). Sneezing was positively correlated with multiple markers: Alternaria ( P &lt; .024), interleukin-13 ( P &lt; .027), MBP ( P &lt; .034), and interleukin-5 ( P &lt; .019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nasal endoscopy, not CT imaging, has the strongest correlation with the 2 cardinal symptoms of congestion and runny nose in CRS patients; these correlate with biomarkers of eosinophilic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489417701939","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T02:40:59Z","timestamp":1491360059000},"page":"455-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation of Symptoms, Clinical Signs, and Biomarkers of Inflammation in Postsurgical Chronic Rhinosinusitis"],"prefix":"10.1177","volume":"126","author":[{"given":"Samuel D.","family":"Racette","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Gromo Institute and Sinus Center, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan C.","family":"Wijewickrama","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Gromo Institute and Sinus Center, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayvel","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention & Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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