{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:35:27Z","timestamp":1777426527985,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Regulated on activation normal T cell expressed and secreted (RANTES) and eotaxin-2 have been postulated to be responsible for eosinophilia in chronically inflamed nasal mucosa. This study evaluated mucosal production of RANTES and eotaxin-2 in patients with perennial allergic rhinitis (PAR) and nonallergic and allergic form of chronic rhinosinusitis with nasal polyps (CRSwNP) before and after nasal corticosteroid treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty patients with PAR, 20 nonallergic and 20 allergic CRSwNP patients, and 20 healthy controls were included. The RANTES and eotaxin-2 levels were measured in nasal secretion samples. The patients with chronic inflammation were treated with fluticasone furoate nasal spray for 2 weeks. Cytological examination and measurement of RANTES and eotaxin-2 in nasal fluid were performed before and after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The levels of RANTES were higher in patients with PAR ( P &lt; .05) and nonallergic ( P &lt; .01) and allergic CRSwNP patients ( P &lt; .001) compared to controls. Eotaxin-2 levels were higher in all 3 inflammation groups compared to healthy subjects ( P &lt; .001). After the treatment, we found a significant decrease of RANTES and eotaxin-2 concentrations ( P &lt; .001) in all 3 groups of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The levels of RANTES and eotaxin-2 in nasal fluid could be reliable markers for assessing corticosteroid administration outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489417713505","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T01:22:25Z","timestamp":1496798545000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis"],"prefix":"10.1177","volume":"126","author":[{"given":"Cveta","family":"\u0160padijer Mirkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia"},{"name":"Department of Otorhinolaryngology, Clinical Hospital Centre Kosovska Mitrovica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Peri\u0107","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biserka","family":"Vukomanovi\u0107 \u0110ur\u0111evi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Vojvodi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, Division of Clinical and Experimental Immunology, Faculty of Medicine, Military Medical Academy, Belgrade, 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