{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:35:50Z","timestamp":1777426550980,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the role of biologic therapy on sinonasal symptoms and objective outcomes in chronic rhinosinusitis with nasal polyposis (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, OVID MEDLINE, and Cochrane Central were reviewed from 2000 to 2015. Inclusion criteria included English-language studies containing original data on biologic therapy in CRSwNP patients with reported outcome measures. Two investigators independently reviewed all manuscripts and performed quality assessment and quantitative meta-analysis using validated tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 495 abstracts identified, 7 studies fulfilled eligibility: 4 randomized control trials (RCT), 1 case-control, and 2 case series. Outcome measures included nasal polyp score (NPS,6), computer tomography score (5), and symptom scores (5). Meta-analysis was performed on 5 studies: Anti-IL5 therapy (mepolizumab\/reslizumab) and anti-IgE therapy (omalizumab) demonstrated a standard mean difference of NPS improvement of \u22120.66 (95% CI, \u22121.24 to \u22120.08) and \u22120.75 (95% CI, \u22121.93 to 0.44), respectively, between biologic therapy and placebo. Quality assessment indicated a low to moderate risk of bias for the RCTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Biologic therapies may prove beneficial in the treatment of recalcitrant nasal polyposis in select populations. In meta-analysis, anti-IL5 therapy demonstrates a reduction in nasal polyp score. Anti-IgE therapy reduces nasal polyp score in patients with severe comorbid asthma. Additional high-level evidence is needed to assess clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489417731782","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T08:01:16Z","timestamp":1505548876000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Anti-IgE and Anti-IL5 Biologic Therapy in the Treatment of Nasal Polyposis: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"126","author":[{"given":"Alexander","family":"Rivero","sequence":"first","affiliation":[{"name":"Kaiser Permanente, Oakland, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Liang","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, Oakland, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"bibr1-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S29977"},{"key":"bibr2-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"bibr3-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7544"},{"key":"bibr4-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3950"},{"key":"bibr5-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112374"},{"key":"bibr6-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02316.x"},{"key":"bibr7-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.022"},{"key":"bibr8-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.056"},{"key":"bibr9-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"bibr10-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.019"},{"key":"bibr11-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70151-9"},{"key":"bibr12-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.001"},{"key":"bibr13-0003489417731782","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin09.144"},{"key":"bibr14-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3613"},{"key":"bibr15-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111593"},{"key":"bibr16-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1159\/000128659"},{"key":"bibr17-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02709.x"},{"key":"bibr18-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20804"},{"key":"bibr19-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21685"},{"key":"bibr20-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.122458"},{"key":"bibr21-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21182"},{"key":"bibr22-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800407"},{"key":"bibr23-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00043305"},{"key":"bibr24-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2500\/105065801781329400"},{"key":"bibr25-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"bibr26-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"bibr27-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.031"},{"key":"bibr28-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.047"},{"key":"bibr29-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3060"},{"key":"bibr30-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.01.024"},{"key":"bibr31-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.152835"},{"key":"bibr32-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"bibr34-0003489417731782","doi-asserted-by":"publisher","DOI":"10.2500\/105065892781874829"},{"issue":"4","key":"bibr35-0003489417731782","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1542\/peds.73.4.526","volume":"73","author":"Rachelefsky GS","year":"1984","journal-title":"Pediatrics"},{"key":"bibr36-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f4178f"},{"key":"bibr37-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0396OC"},{"key":"bibr38-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00024-2015"},{"key":"bibr39-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"bibr40-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03496-6"},{"key":"bibr41-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1871"},{"key":"bibr42-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_2.S79"},{"issue":"3","key":"bibr43-0003489417731782","first-page":"162","volume":"43","author":"Zhang N","year":"2005","journal-title":"Rhinology"},{"issue":"43","key":"bibr44-0003489417731782","first-page":"201","volume":"11","author":"Pokharel M","year":"2013","journal-title":"Kathmandu Univ Med J KUMJ"},{"key":"bibr45-0003489417731782","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19330"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489417731782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489417731782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489417731782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:31:45Z","timestamp":1777375905000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0003489417731782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,16]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1177\/0003489417731782"],"URL":"https:\/\/doi.org\/10.1177\/0003489417731782","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,16]]}}}