{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:27:20Z","timestamp":1780424840927,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006107","name":"Gachon University Gil Medical Center","doi-asserted-by":"publisher","award":["JJ2012-07"],"award-info":[{"award-number":["JJ2012-07"]}],"id":[{"id":"10.13039\/501100006107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Subglottic stenosis remains a clinical challenge. The aim of this study was to evaluate the effect of human adipose tissue\u2013derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>Ninety-six 13-week-old male rats were enrolled in this study. They were divided into 3 groups as normal control (NC) group, a subglottic injury and media injection (SM) group, and a subglottic injury and media-stem cell injection (SMSC) group. The hAMSCs were immediately injected into subglottis after injury. Histologic characteristics of subglottis; the mRNA expressions of interleukin-1\u03b2, cyclooxygenase-2, tumor growth factor-\u03b2 and basic fibroblast growth factor; and hAMSCs\u2019 survival were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The hAMSCs survived in the subglottis of the rat until 10 days after implantation. The NC and SMSC groups had a significantly wider subglottic lumen and thinner lamina propria than the SM group at 56 days after injury. Collagen intensity of subglottis was significantly higher in the SM group than in the NC and SMSC groups at 28 days after injury. Gene expression didn\u2019t show significant difference between the SM group and the SMSC group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The hAMSCs injection was found to be helpful for preventing subglottic stenosis in a rat model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489417739920","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T05:33:41Z","timestamp":1511933621000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Human Adipose Tissue\u2013Derived Mesenchymal Stem Cells in Rat\u2019s Subglottic Stenosis Model"],"prefix":"10.1177","volume":"127","author":[{"given":"Seyeon","family":"Oh","sequence":"first","affiliation":[{"name":"Center for Genomics and Proteomics & Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Gachon University, Gil Medical Center, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kwan","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Gachon University, Gil Medical Center, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghee","family":"Byun","sequence":"additional","affiliation":[{"name":"Center for Genomics and Proteomics & Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea"},{"name":"Department of Anatomy and Cell Biology, Gachon University, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Hyun","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Gachon University, Gil Medical Center, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"bibr1-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-3840(98)80014-2"},{"key":"bibr2-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.7.694"},{"key":"bibr3-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100412"},{"key":"bibr4-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.08.041"},{"key":"bibr5-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2807"},{"key":"bibr6-0003489417739920","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00201"},{"key":"bibr7-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2015.0277"},{"key":"bibr8-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.10.1191"},{"key":"bibr9-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1159\/000318675"},{"key":"bibr10-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9570-8"},{"key":"bibr11-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61715-7"},{"key":"bibr12-0003489417739920","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60737-5"},{"key":"bibr13-0003489417739920","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.734930"},{"key":"bibr14-0003489417739920","first-page":"2059","volume":"8","author":"Jia Y","year":"2016","journal-title":"Am J Trans Res"},{"key":"bibr15-0003489417739920","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12902"}],"container-title":["Annals of Otology, Rhinology &amp; 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