{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:38:23Z","timestamp":1777426703886,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The aim of this study was to analyze the sensitivity and specificity of non-echoplanar (non-EPI) diffusion-weighted (DW) magnetic resonance imaging (MRI) for the detection of cholesteatoma, with a focus on its value as an adjunct to clinical examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective cohort study, 92 cases were divided into 2 groups: \u201cclinically cholesteatoma\u201d ( n = 79) and \u201cclinically no cholesteatoma\u201d ( n = 13). Non-EPI DW MRI was performed preoperatively in all cases. The presence of a cholesteatoma was assessed by clinicians otoscopically, by neuroradiologists on non-EPI DW MRI, by the surgeon intraoperatively, and finally by the pathologist postoperatively. Data analysis was performed for specificity, sensitivity, positive predictive value, negative predictive value, and interrater variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The sensitivity and specificity were 89.3% and 75%, respectively, in the \u201cclinically cholesteatoma\u201d group and 0% and 100% in the \u201cclinically no cholesteatoma\u201d group. Non-EPI DW MRI had a positive predictive value of 98.5% when cholesteatoma was suspected clinically and a negative predictive value of 84.6% when cholesteatoma was not suspected clinically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>If cholesteatoma is suspected clinically, non-EPI DW MRI is not necessary. If there is no clinical suspicion of cholesteatoma in second-look situations, sensitivity is low and serial follow-up MRI with long intervals is advised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489418800833","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T07:30:17Z","timestamp":1537601417000},"page":"919-925","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role of Non-Echoplanar Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Primary Cholesteatoma and Cholesteatoma Recidivism as an Adjunct to Clinical Evaluation"],"prefix":"10.1177","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-2350","authenticated-orcid":false,"given":"Roman D.","family":"Laske","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Bar\u00e1th","sequence":"additional","affiliation":[{"name":"Medical Radiological Institute Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schuknecht","sequence":"additional","affiliation":[{"name":"Medical Radiological Institute Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"R\u00f6\u00f6sli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"bibr1-0003489418800833","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2017.3363"},{"key":"bibr2-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-2198-8"},{"key":"bibr3-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1577-z"},{"key":"bibr4-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23759"},{"key":"bibr5-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815613073"},{"key":"bibr6-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000013"},{"key":"bibr7-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000484"},{"key":"bibr8-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"bibr9-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25981"},{"key":"bibr10-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.123446"},{"key":"bibr11-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854024"},{"key":"bibr12-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816683342"},{"key":"bibr13-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12762"},{"key":"bibr14-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0268-3"},{"key":"bibr15-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10118"},{"key":"bibr16-0003489418800833","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0160-2"}],"container-title":["Annals of Otology, Rhinology &amp; 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