{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:38:23Z","timestamp":1777426703876,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine pediatric neuroblastoma survival and management in the head and neck compared to other body sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective analysis of a large population database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients in the Surveillance, Epidemiology, and End Results (SEER) database with neuroblastoma, NOS; ganglioneuroblastoma; or olfactory neuroblastoma diagnosed from birth to 18 years between 1973 and 2014 were included. These patients were classified into 1 of 3 categories based on primary tumor site: head and neck, adrenal, and \u201cother.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four thousand five hundred neuroblastoma cases were identified. One hundred seventy-five (3.9%) occurred in the head and neck, 1,934 (43.0%) occurred in the adrenal gland, and 2,391 (53.1%) occurred in \u201cother\u201d sites. The mean age at diagnosis was 4.21 years in the head and neck, 2.23 years in the adrenal gland, and 2.47 years in the \u201cother\u201d cohorts ( P &lt; .001). Two- and 5-year disease-specific survival rates were 89% and 84% in the head and neck versus 77% and 65% in the adrenal and 84% and 77% in the \u201cother\u201d cohorts ( P &lt; .001). The risk of disease-specific death (DSD) was higher in the adrenal cohort (adjusted hazard ratio [aHR] = 2.85; 95% CI, 1.54-5.27) compared to the head and neck cohort. Patients treated with surgery only had the lowest risk of DSD (aHR = 0.22; 95% CI, 0.13-0.35) compared to all other studied treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results demonstrate that primary neuroblastoma of the head and neck has a better prognosis than primary neuroblastoma of the adrenal gland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489418818586","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T07:45:17Z","timestamp":1545205517000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Factors Associated With the Improved Survival of Head and Neck Neuroblastomas Compared to Other Body Sites"],"prefix":"10.1177","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-1320","authenticated-orcid":false,"given":"Matthew R.","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Ryan","family":"Camilon","sequence":"additional","affiliation":[{"name":"Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler A.","family":"Janz","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Orlando, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica R.","family":"Levi","sequence":"additional","affiliation":[{"name":"Boston Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"bibr1-0003489418818586","unstructured":"American Cancer Society. Key statistics about neuroblastoma. https:\/\/www.cancer.org\/cancer\/neuroblastoma\/about\/key-statistics.html. Accessed February 22, 2018."},{"key":"bibr2-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2011.03.011"},{"key":"bibr3-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.04.013"},{"key":"bibr4-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2008.00983.x"},{"key":"bibr5-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.1621"},{"key":"bibr6-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010908"},{"key":"bibr7-0003489418818586","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.3.461"},{"key":"bibr8-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3431-4"},{"key":"bibr9-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.11.011"},{"key":"bibr10-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2003.08.046"},{"key":"bibr11-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072390"},{"key":"bibr12-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90234-C"},{"key":"bibr13-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32721"},{"key":"bibr14-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-1049-7"},{"key":"bibr15-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00499-2"},{"key":"bibr16-0003489418818586","unstructured":"National Institutes of Health National Cancer Institute Surveillance, Epidemiology, and End Results Program. SEER incidence data, 1973-2015 (Including July-December 2005 Hurricane Katrina impacted Louisiana cases). https:\/\/seer.cancer.gov\/data\/. Accessed April 22, 2018."},{"key":"bibr17-0003489418818586","unstructured":"Surveillance, Epidemiology and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2016 Sub (1973-2014) <Katrina\/Rita Population Adjustment> National Cancer Institute, DCCPS, Surveillance Research Program, released April 2017, based on the November 2016 submission."},{"key":"bibr18-0003489418818586","unstructured":"Surveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov\/seerstat) version <version 8.3.4>"},{"key":"bibr19-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.010"},{"key":"bibr20-0003489418818586","unstructured":"National Cancer Institute. Neuroblastoma Treatment (PDQ\u00ae)\u2013Health Professional Version. https:\/\/www.cancer.gov\/types\/neuroblastoma\/hp\/neuroblastoma-treatment-pdq#section\/_203. Accessed August 21, 2018."},{"key":"bibr21-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.9990"},{"key":"bibr22-0003489418818586","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S4878"},{"key":"bibr23-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2906"},{"key":"bibr24-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014415"},{"key":"bibr25-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-011514-023121"},{"key":"bibr26-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90577-4"},{"key":"bibr27-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22398"},{"key":"bibr28-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-017-0412-z"},{"key":"bibr29-0003489418818586","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0521-3"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489418818586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489418818586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489418818586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:32:21Z","timestamp":1777375941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489418818586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1177\/0003489418818586"],"URL":"https:\/\/doi.org\/10.1177\/0003489418818586","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}