{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:14:51Z","timestamp":1777421691556,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6_suppl","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20390443"],"award-info":[{"award-number":["20390443"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20791206"],"award-info":[{"award-number":["20791206"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22591911"],"award-info":[{"award-number":["22591911"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23791911"],"award-info":[{"award-number":["23791911"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25462689"],"award-info":[{"award-number":["25462689"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25861572"],"award-info":[{"award-number":["25861572"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to clarify the role of serum phosphorylcholine (PC)\u2013specific immunoglobulin M (IgM) as a natural antibody against infectious diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The relationship between serum PC-specific IgM level and C-reactive protein level or white blood cell counts was examined in patients with severe upper respiratory tract infections (ie, acute epiglottitis and peritonsillar abscess).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PC-specific IgM level was significantly negatively correlated with C-reactive protein level and white blood cell count. In addition, C-reactive protein level and white blood cell count was significantly lower in women than in men, whereas PC-specific IgM level was significantly higher in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PC-specific IgM is suggested to have protective and suppressive effects against the progression of infectious and inflammatory reactions. Higher levels of PC-specific IgM in women might be one of the reasons why the incidence and severity of acute epiglottitis and peritonsillar abscess are lower in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489419835568","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:59:27Z","timestamp":1557968367000},"page":"111S-116S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections"],"prefix":"10.1177","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-9902","authenticated-orcid":false,"given":"Junichiro","family":"Ohori","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Jimura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kurono","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"bibr1-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28610-0"},{"key":"bibr2-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.631"},{"key":"bibr3-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.10.014"},{"key":"bibr4-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.01.002"},{"key":"bibr5-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.07.030"},{"key":"bibr6-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.097"},{"key":"bibr7-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192399699"},{"key":"bibr8-0003489419835568","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.4049\/jimmunol.155.5.2557","volume":"155","author":"Szalai AJ","year":"1995","journal-title":"J Immunol"},{"key":"bibr9-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80372-X"},{"key":"bibr10-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0025-4"},{"key":"bibr11-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00042-6"},{"key":"bibr12-0003489419835568","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.128.5.2374","volume":"128","author":"Yother J","year":"1982","journal-title":"J Immunol"},{"key":"bibr13-0003489419835568","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.18.5.1102-1107.1983"},{"key":"bibr14-0003489419835568","first-page":"88","volume":"294","author":"Briles DE","year":"1981","journal-title":"Streptococcus pneumoniae. 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