{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:21:11Z","timestamp":1792840871042,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to determine whether patients with rhinitis medicamentosa (RM) have an increased odds of having an opioid use disorder (OUD) and which characteristics may predict this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The authors conducted a retrospective case control study of patients 18\u2009years and older who presented to the otolaryngology clinic at an academic medical center from January 2013 through December 2017. Cases, defined as patients who presented with excessive decongestant nasal spray usage based on history, were matched to control patients who presented with chronic rhinitis and did not report regular nasal decongestant usage. The charts were reviewed for patients that carried a problem of opioid abuse, identified using ICD-9 codes 304.XX or ICD-10 codes F11.XX. The primary outcome of this study was the odds of having an OUD. Secondary outcomes were assessed by summary statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred and thirty-one cases of RM were matched to 1871 controls of chronic rhinitis. Seven cases (5.3%) and 24 (1.3%) controls had a diagnosis of OUD, consistent with an odds ratio of 3.98 for opioid abuse in patients with RM (95% CI: 1.47-9.71). Oxymetazoline was used by 85.5% (n\u2009=\u2009112) of patients with RM. Thirty-six patients (27.1%) with RM underwent nasal surgery following a diagnosis of RM, of which twenty patients (55.6%) were prescribed opioids following the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>RM is associated with increased odds of having an OUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489419880576","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:57:38Z","timestamp":1570165058000},"page":"164-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Should Excess Topical Decongestant Use Raise a Red Flag? Rhinitis Medicamentosa and Opioid Use Disorder"],"prefix":"10.1177","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-7260","authenticated-orcid":false,"given":"Aneesh","family":"Patel","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Levi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Otolaryngology, Boston University Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Brook","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Otolaryngology, Boston University Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"bibr1-0003489419880576","volume-title":"Results from the 2016 National Survey on Drug Use and Health: Detailed Tables","author":"Center for Behavioral Health Statistics and Quality","year":"2017"},{"key":"bibr2-0003489419880576","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.03.007"},{"key":"bibr3-0003489419880576","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6712a1"},{"issue":"10","key":"bibr4-0003489419880576","first-page":"1","volume":"65","author":"Warner M","year":"2016","journal-title":"Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat 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