{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:25:20Z","timestamp":1790706320406,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Despite studies reporting a possible association between malignant otitis externa (MOE) and diabetes, there are no large-scale population-based empirical studies. This nationwide, population-based case-control study explored the association of MOE occurrence with previously diagnosed diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were retrieved from Taiwan\u2019s National Health Insurance Research Database, 753 patients with MOE (cases) and 2\u2009259 propensity score-matched patients without MOE (controls). Multiple logistic regressions were conducted to examine the association of MOE with previously diagnosed diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 728 (24.2%) out of 3\u2009012 sample patients had diabetes prior to the index date. Chi-square test revealed a significant difference in diabetes prevalence among cases and controls (54.8% vs 13.9%, p\u2009&lt;\u20090.001). Simple logistic regression showed the odds ratio for prior diabetes among cases versus controls was 7.50 (95% CI, 6.22~9.03). The adjusted odds ratio of prior diabetes for cases versus controls was 10.07 (95% CI, 8.15~12.44) after adjusting for patient demographics and medical co-morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study found an association between MOE and diabetes. One clinical practice implication of our study is that when a patient with diabetes complains of otalgia or otorrhea, and physical examination shows swelling of the ear canal or granulation growth, physicians should consider the possibility of MOE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489419901139","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T08:45:36Z","timestamp":1579855536000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Malignant Otitis Externa is Associated with Diabetes: A Population-Based Case-Control Study"],"prefix":"10.1177","volume":"129","author":[{"given":"Tzong-Hann","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Taipei City Hospital, Taipei"},{"name":"Department of Speech, Language and Audiology, National Taipei University of Nursing and 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Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Taipei City Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wei","family":"Kao","sequence":"additional","affiliation":[{"name":"Big Data Research Center, Taipei Medical University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Chang","family":"Shia","sequence":"additional","affiliation":[{"name":"Big Data Research Center, Taipei Medical University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-6146","authenticated-orcid":false,"given":"Herng-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Sleep Research Center, Taipei Medical University Hospital, Taipei"},{"name":"School of Health Care Administration, College of Management, Taipei Medical University, 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