{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:04:07Z","timestamp":1781571847868,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify whether combination therapy with mucolytics and proton pump inhibitors (PPIs) leads to faster and more effective symptomatic relief in patients with laryngopharyngeal reflux (LPR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients diagnosed as LPR with a reflux symptom index (RSI) \u2265 13 and a reflux finding score (RFS) \u2265 7 were enrolled in this prospective study. Patients were randomly allocated to control (PPI only) or experimental (PPI + mucolytics) groups and changes in RSI and RFS values were assessed at 1- and 3-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred sixteen patients were randomly allocated into either the control group ( n = 59) or the experimental group ( n = 57). The RSI and RFS scores significantly decreased in both groups (all P &lt; .001) after 1 month of treatment; however, there was no significant difference in RSI change between groups ( P = .223). After 3\u2009months of treatment, there remained no significant difference in RSI change between groups ( P = .592).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Combination therapy with mucolytics and PPI compared to PPI alone did not lead to faster or more effective symptomatic relief in LPR patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489420913592","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T10:16:21Z","timestamp":1584526581000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux"],"prefix":"10.1177","volume":"129","author":[{"given":"Minsuk","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Eulji University School of Medicine, Eulji Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyuk","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eulji University School of Medicine, Eulji Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eulji University School of Medicine, Eulji Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-0708","authenticated-orcid":false,"given":"Minsu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Korea University Hospital, Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"bibr1-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"bibr2-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.10.006"},{"key":"bibr3-0003489420913592","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2014.57.10.698"},{"key":"bibr4-0003489420913592","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/014556130208100101","volume":"81","author":"Koufman JA.","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"bibr5-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000486"},{"key":"bibr6-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"bibr7-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4142-y"},{"key":"bibr8-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00001"},{"key":"bibr9-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"bibr10-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000176547.90094.ac"},{"key":"bibr11-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.10.009"},{"key":"bibr12-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5813"},{"key":"bibr13-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24738"},{"key":"bibr14-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5079-0"},{"key":"bibr15-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/983653"},{"issue":"2","key":"bibr16-0003489420913592","first-page":"106","volume":"67","author":"Pozzi E.","year":"2007","journal-title":"Monaldi Arch Chest Dis"},{"issue":"11","key":"bibr17-0003489420913592","first-page":"757","volume":"51","author":"Dabirmoghaddam P","year":"2013","journal-title":"Acta Medica Iran"},{"key":"bibr18-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163746.81766.45"},{"key":"bibr19-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419858090"},{"key":"bibr20-0003489420913592","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2017.00738"},{"key":"bibr21-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.01.001"},{"key":"bibr22-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02140.x"},{"key":"bibr23-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02943.x"},{"key":"bibr24-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13737"},{"key":"bibr25-0003489420913592","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5041-1"}],"container-title":["Annals of Otology, Rhinology &amp; 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