{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:48:03Z","timestamp":1777427283118,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess voice outcomes using the novel technique of in-office laryngeal electromyography-guided vocal fold injections (LEVFI) with hyaluronic acid to treat glottal insufficiency. Secondary objectives included determining the complication\/completion rates and if any factors were associated with improved voice outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective review of patients who received their first LEVFI from August 2017 to December 2018. Three- and six-month voice outcomes were assessed. Outcomes included voice handicap index-10 (VHI-10), maximum phonation time (MPT), perceptual analysis of voice (GRBAS), fundamental frequency, and stroboscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 121 eligible patients (55.4% male, age 63.7\u2009years), 94 (77.7%) had complete 3-month data and 59 (48.8%) had complete 6-month data. VHI-10 was significantly improved from 25.7\u2009\u00b1\u20097.5 to 20.9\u2009\u00b1\u200910.9 at 3\u2009months ( P\u2009&lt;\u2009.001) and to 19.1\u2009\u00b1\u200911.5 at 6\u2009months ( P\u2009&lt;\u2009.001). MPT improved from 6.2\u2009\u00b1\u20095.4\u2009seconds to 9.4\u2009\u00b1\u20097.1\u2009seconds at 3\u2009months ( P\u2009&lt;\u2009.001) and to 11.3\u2009\u00b1\u20098.2\u2009seconds at 6\u2009months ( P\u2009&lt;\u2009.001). GRBAS was improved in 74.8% of patients ([65.2, 82.8] 95% CI) at 3\u2009months and 80.8% ([69.9, 89.1]) 95% CI) at 6\u2009months. Stroboscopy showed a glottic gap improvement in 74.8% of patients ([65.8, 82.4] 95% CI) at 3\u2009months and in 80.3% ([65.9, 88.5] 95% CI) at 6\u2009months. Fundamental frequency was unchanged, as expected. Multivariate analysis reported that no factors were associated with better voice outcomes. Overall, 177\/181 (97.8%) injections were completed. There were no complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In-office LEVFI is an effective, novel technique to treat glottic insufficiency with improved voice outcomes, high completion rate, and no significant complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489420931556","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T08:11:11Z","timestamp":1591085471000},"page":"1063-1070","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Laryngeal Electromyography-Guided Hyaluronic Acid Vocal Fold Injections for Glottic Insufficiency"],"prefix":"10.1177","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-836X","authenticated-orcid":false,"given":"Alice Q.","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"School of Population and Public Health, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Population and Public Health, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"bibr1-0003489420931556","unstructured":"Rosen CA, Simpson B. 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