{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:49:04Z","timestamp":1783784944763,"version":"3.55.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>LMNA-associated familial partial lipodystrophy (FPLD) is a rare autosomal dominant A-type laminopathy characterized by variable loss and redistribution of subcutaneous adipose tissue, dyslipidemia, and insulin resistance. Though A-type lamins play a key role in nuclear membrane structure and regulation of cell proliferation, an association between cancer and LMNA-associated FPLD has not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>This report outlines the case of two biological sisters with LMNA-associated FPLD who developed hypopharyngeal squamous cell carcinoma in the absence of any other risk factors for head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These observations prompt further investigation into the potential role of A-type lamins in the development and progression of head and neck cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489420933645","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T02:03:02Z","timestamp":1591754582000},"page":"1243-1246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypopharyngeal Squamous Cell Carcinoma in Sisters with LMNA Associated Familial Partial Lipodystrophy: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-1405","authenticated-orcid":false,"given":"Stephanie J.","family":"Youssef","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Macielak","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Schimmenti","sequence":"additional","affiliation":[{"name":"Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Chatzopoulos","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"bibr1-0003489420933645","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2016.309"},{"key":"bibr2-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.015"},{"key":"bibr3-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1065-4"},{"key":"bibr4-0003489420933645","author":"Akinci B","year":"2018","journal-title":"Endotext"},{"issue":"1","key":"bibr5-0003489420933645","first-page":"59","volume":"86","author":"Garg A","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"bibr6-0003489420933645","volume":"11","author":"Venugopal R","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"bibr7-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(94)90032-9"},{"issue":"1","key":"bibr8-0003489420933645","first-page":"1","volume":"2017","author":"Fountas A","year":"2017","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"bibr9-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1159\/000354716"},{"key":"bibr10-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0268"},{"key":"bibr11-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.07.038"},{"key":"bibr12-0003489420933645","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.01.003"},{"issue":"11","key":"bibr13-0003489420933645","first-page":"20690","volume":"8","author":"Yi YX","year":"2015","journal-title":"Int J Clin Exp Med"}],"container-title":["Annals of Otology, Rhinology &amp; 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