{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:57:34Z","timestamp":1789649854148,"version":"4.0.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary objectives were to report oncologic outcomes of transoral laser microsurgery with potassium-titanyl-phosphate (KTP) laser (TLM-KTP) ablation of early glottic cancer (EGC). The secondary objectives were to report vocal outcomes and to analyze factors that might influence outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A multi-institutional, retrospective analysis of consecutive patients treated for T1 or T2 glottic squamous cell carcinoma undergoing TLM-KTP ablation with at least 2\u2009years of follow-up was performed. Patients with prior radiation or surgery for laryngeal disease were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures included:<\/jats:title>\n                    <jats:p>surgical failures requiring radiation or laryngectomy, disease-specific survival (DSS), and overall survival (OS). Secondary outcome measures included: pre- and postoperative Voice Handicap Index-10 (VHI-10) scores. The effects of smoking status, stage, and anterior commissure involvement on outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall 88 patients met inclusion criteria (83% male, 79.5% current or former smokers). Mean age was 68 (standard deviation (SD): 12). Mean follow-up was 39.5\u2009months (SD: 15.3). Staging included 50 T1a, 21 T1b, and 20 T2 tumors, including three metachronous second primaries. Radiation and\/or laryngectomy avoidance was achieved in 87\/88 (98.9%) of patients, inclusive of 24 patients requiring KTP re-treatments. Two patients had biopsy-proven recurrence (2.3%), but only 21 of 24 re-treated patients received a formal biopsy. No patients died from laryngeal cancer. DSS and OS were 100% and 92.3%, respectively. The mean VHI-10 scores were 19.3 preoperatively, 3.8 at 6-months postop, and 3.8 at 2-years postop. Smokers had a longer interval to re-treatment ( P\u2009=\u2009.03), patients with T2 lesions had a shorter interval to re-treatment (0.02), and patients with T2 lesions presented with worse initial VHI-10 scores (0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A multi-institutional, retrospective case series of TLM-KTP ablation of EGC demonstrated excellent oncologic outcomes when close surveillance and proactive re-treatments were utilized. Disease-specific survival, overall survival, and vocal function were excellent. Additional studies are necessary to further analyze the merits and risks of this treatment approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489420938100","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T05:25:50Z","timestamp":1593840350000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["KTP Laser Treatment of Early Glottic Cancer: A Multi-Institutional Retrospective Study"],"prefix":"10.1177","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-1948","authenticated-orcid":false,"given":"Noah P.","family":"Parker","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2014Head and Neck Surgery and Speech and Hearing Sciences, Indiana University, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Weidenbecher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Case Western Reserve, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-3442","authenticated-orcid":false,"given":"Aaron D.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, NorthShore University Health System, Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-9687","authenticated-orcid":false,"given":"David G.","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,4]]},"reference":[{"key":"bibr1-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20740"},{"key":"bibr2-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00295-X"},{"issue":"6","key":"bibr3-0003489420938100","first-page":"603","volume":"38","author":"Higgins KM","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"bibr4-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23504"},{"key":"bibr5-0003489420938100","first-page":"283","volume":"12","author":"Fraenkel B.","year":"1886","journal-title":"Archiv Fu Klinische Chirurgie"},{"key":"bibr6-0003489420938100","first-page":"119","volume":"40","author":"Lynch RC.","year":"1920","journal-title":"Trans Am Laryngol Assoc"},{"key":"bibr7-0003489420938100","first-page":"411","volume":"16","author":"New GB","year":"1941","journal-title":"Mayo Clin Proc"},{"key":"bibr8-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197212000-00009"},{"key":"bibr9-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100606"},{"key":"bibr10-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.9.1399"},{"key":"bibr11-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90267-2"},{"key":"bibr12-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10361"},{"key":"bibr13-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.9.965"},{"key":"bibr14-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500803"},{"key":"bibr15-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815577103"},{"issue":"10","key":"bibr16-0003489420938100","first-page":"17206","volume":"8","author":"Du G","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr17-0003489420938100","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2018.00990"},{"key":"bibr18-0003489420938100","first-page":"197","volume-title":"Surgery of Larynx and Trachea","volume":"2010","author":"Eckel HE"},{"key":"bibr19-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00025"},{"key":"bibr20-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/00034894081170S701"},{"key":"bibr21-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900010310"},{"key":"bibr22-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"bibr23-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414538936"},{"key":"bibr24-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26853"},{"key":"bibr25-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418806914"},{"key":"bibr26-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25474"},{"key":"bibr27-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"bibr28-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"bibr29-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25005"},{"key":"bibr30-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415619177"},{"key":"bibr31-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418818852"},{"key":"bibr32-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1347826"},{"key":"bibr33-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3851-y"},{"key":"bibr34-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300403"},{"key":"bibr35-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500905"},{"key":"bibr36-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.041"},{"key":"bibr37-0003489420938100","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200302"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489420938100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0003489420938100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0003489420938100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:33:41Z","timestamp":1777376021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0003489420938100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,4]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/0003489420938100"],"URL":"https:\/\/doi.org\/10.1177\/0003489420938100","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,4]]}}}