{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:49:12Z","timestamp":1777427352109,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Department of Health and Family Planning Commission of Zhejiang Province","award":["#2017KY380"],"award-info":[{"award-number":["#2017KY380"]}]},{"name":"Department of Health and Family Planning Commission of Zhejiang Province","award":["#2017KY407"],"award-info":[{"award-number":["#2017KY407"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Refractory otomycosis is a common condition that is difficult to treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of 1% topical voriconazole drops in the treatment of otomycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective analysis was conducted from November 2017 to November 2019. Patients who had refractory otomycosis without tympanic membrane perforation confirmed by microbial culture and fluorescent staining were included in the study. All patients were treated with 1% topical voriconazole drops hourly at daytime for 2\u2009weeks. Evaluation of effectiveness was conducted 1\u2009month after the completion of topical voriconazole treatment. Before and after topical voriconazole treatment, hearing tests were performed in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty-five patients were included in this study. The reasons for refractoriness were resistant recurrence to imidazole drugs (50 cases, 90.9%) and difficulty in cleaning the external auditory canal (5 cases, 9.1%). The most common strain was Aspergillus terreus (50.9%), followed by Aspergillus flavus (29.1%), Aspergillus niger (10.9%), and Aspergillus fumigatus (9.1%). After 2\u2009weeks of treatment with 1% topical voriconazole drops, otomycosis in all patients was resolved. There was no significant change in bone conduction before and after topical voriconazole treatment (paired t-test, P\u2009=\u20090.5023; linear correlation analysis, R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.98; equation, y\u2009=\u20091.003 x\u22120.284). Adverse effects, such as blurred vision and phototoxicity, were not observed in any patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation within 2\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489420946783","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T07:43:37Z","timestamp":1596872617000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation"],"prefix":"10.1177","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-9195","authenticated-orcid":false,"given":"Shoude","family":"Zhang","sequence":"first","affiliation":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Jin","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"bibr1-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12979"},{"key":"bibr2-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-015-9864-7"},{"key":"bibr3-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319851499."},{"key":"bibr4-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0918-2"},{"issue":"5","key":"bibr5-0003489420946783","first-page":"A5231","volume":"63","author":"Arndal E","year":"2016","journal-title":"Dan Med J"},{"key":"bibr6-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116008598"},{"key":"bibr7-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2017.04.004"},{"key":"bibr8-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/239730"},{"issue":"3","key":"bibr9-0003489420946783","first-page":"564","volume":"30","author":"Anwar K","year":"2014","journal-title":"Pak J Med Sci"},{"issue":"96","key":"bibr10-0003489420946783","first-page":"41","volume":"30","author":"Kiakojori K","year":"2018","journal-title":"Iran J Otorhinolaryngol"},{"key":"bibr11-0003489420946783","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2018.00276"},{"key":"bibr12-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1626702"},{"issue":"12","key":"bibr13-0003489420946783","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1358\/dot.2015.51.12.2421058","volume":"51","author":"Peyton LR","year":"2015","journal-title":"Drugs Today"},{"key":"bibr14-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700557"},{"key":"bibr15-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01700-08"},{"key":"bibr16-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00683-16"},{"key":"bibr17-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2018.03.009"},{"key":"bibr18-0003489420946783","first-page":"391","volume":"4","author":"Al-Badriyeh D","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"bibr19-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00841.x"},{"key":"bibr20-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215114001273"},{"key":"bibr21-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01220-08"},{"key":"bibr22-0003489420946783","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12834"}],"container-title":["Annals of Otology, Rhinology &amp; 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