{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:41:52Z","timestamp":1791830512293,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Tinnitus can be a chronic symptom that brings disability and distress. Some studies suggested that gabapentin might be effective on tinnitus relief. The objective of the study is to perform a systematic review in order to evaluate the efficacy of oral gabapentin in patients with tinnitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature search was conducted in English and following the recommendations from PRISMA. The terms used were: (\u201ctinnitus\u201d OR \u201csubjective tinnitus\u201d) AND (\u201cgabapentin\u201d). The study selection was performed following the eligibility criteria in accordance to the PICOS (population, intervention, comparison, outcome, study design) strategy\u2014patients with tinnitus; oral gabapentin; placebo; reduction of tinnitus severity questionnaires scores; prospective, double-blind, randomized controlled trial, respectively. The selected studies were included in qualitative synthesis. The studies were analyzed according to Joanna Briggs Institute\u2019s critical appraisal checklist for randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred twenty-one studies were found in 9 databases and 8 studies were found in gray literature. After study selection, 6 articles were read in full. Then, 2 studies were excluded and 4 were included in qualitative synthesis. All 4 articles were analyzed according to critical evaluation checklist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There is insufficient evidence to recommend the use of gabapentin for patients with tinnitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211018921","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T05:16:21Z","timestamp":1622006181000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Gabapentin\u2019s Efficacy in Tinnitus Treatment: A Systematic Review"],"prefix":"10.1177","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-740X","authenticated-orcid":false,"given":"Matheus Pedrosa","family":"Tavares","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University of Bras\u00edlia, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-7589","authenticated-orcid":false,"suffix":"Jr","given":"Fayez","family":"Bahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"bibr1-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1700"},{"key":"bibr2-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60142-7"},{"key":"bibr3-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003853.pub3"},{"key":"bibr4-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115000808"},{"key":"bibr5-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007960.pub2"},{"key":"bibr6-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1159\/000276835"},{"key":"bibr7-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.1.114"},{"key":"bibr8-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1016\/s0074-7696(02)13011-7"},{"key":"bibr9-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1016\/s0920-1211(97)00084-3"},{"key":"bibr10-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010030"},{"key":"bibr11-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1177\/014556130108000211"},{"key":"bibr12-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.07.014"},{"issue":"1","key":"bibr13-00034894211018921","first-page":"30","volume":"8","author":"Shulman A","year":"2002","journal-title":"Int Tinnitus J"},{"issue":"2","key":"bibr14-00034894211018921","first-page":"140","volume":"12","author":"Bahmad FM","year":"2006","journal-title":"Int Tinnitus J"},{"key":"bibr15-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr16-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"bibr17-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0504-9"},{"key":"bibr18-00034894211018921","doi-asserted-by":"publisher","DOI":"10.4103\/0971-7749.124513"},{"key":"bibr19-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000235967.53474.93"},{"key":"bibr20-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.4.390"},{"key":"bibr21-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109000405"},{"issue":"91","key":"bibr22-00034894211018921","first-page":"95","volume":"29","author":"Goljanian Tabrizi A","year":"2017","journal-title":"Iran J Otorhinolaryngol"},{"key":"bibr23-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1044\/1059-0889(2011\/10-0041)"},{"key":"bibr24-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2012.05.002"},{"key":"bibr25-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000216812.65206.CD"},{"key":"bibr26-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1177\/2331216515580272"},{"key":"bibr27-00034894211018921","doi-asserted-by":"publisher","DOI":"10.1177\/2331216517736689"}],"container-title":["Annals of Otology, Rhinology &amp; 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