{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:23:29Z","timestamp":1789910609762,"version":"4.0.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze the oncologic outcomes and risk factors for recurrence in patients who underwent surgery for oropharyngeal squamous cell carcinoma (OPSCC), and in whom adjuvant therapy was not recommended or was declined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective cohort study of patients with OPSCC who were treated with transoral surgery only at a tertiary care academic medical center from April 2010 to March 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-four patients met inclusion criteria. In 16, adjuvant therapy was recommended but declined. There were 8 recurrences, of which 6 had been given recommendations for adjuvant therapy. Of the 8 recurrences, 2 died, 2 are alive with disease, and 4 were successfully salvaged. Five patients died of unrelated causes. Lymphovascular invasion (LVI, P\u2009=\u2009.016) had a significant impact on recurrence, while other pathologic features of the primary tumor such as size, location, human papillomavirus (HPV) status, and margin status did not. Margins were classified as \u201cpositive\u201d in 4 patients, \u201cclose\u201d in 54, and \u201cnegative\u201d in 16. There were 3 local recurrences (4.1%), each of whom had declined adjuvant therapy. Lymph node features such as N-stage ( P\u2009=\u2009.0004), number of positive nodes ( P\u2009=\u2009.0005), and presence of extra-nodal extension (ENE, P\u2009=\u2009.0042) had a statistically significant impact on relapse. Smoking history and surgical approach showed no significant impact on recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients who undergo surgery for HPV-positive OPSCC with negative margins, no PNI, no LVI, and \u22641 positive lymph node without ENE have low risk for recurrence. These patients can likely be safely treated with surgery alone. Patients with these risk factors who decline adjuvant therapy are at risk for recurrence, and should be monitored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211021287","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T01:39:19Z","timestamp":1622425159000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Oropharyngeal Carcinoma Treated with Surgery Alone: Outcomes and Predictors of Failure"],"prefix":"10.1177","volume":"131","author":[{"given":"Joshua D.","family":"Waltonen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7893-3052","authenticated-orcid":false,"given":"Sydney G.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory B.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"bibr1-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814538605"},{"key":"bibr2-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70017-6"},{"key":"bibr3-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"bibr4-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26903"},{"key":"bibr5-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.7.583"},{"key":"bibr6-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817706499"},{"key":"bibr7-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000143"},{"key":"bibr8-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.8841"},{"key":"bibr9-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23610"},{"key":"bibr10-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.08.004"},{"key":"bibr11-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27937"},{"key":"bibr12-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811421298"},{"key":"bibr13-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.6199"},{"key":"bibr14-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28847"},{"key":"bibr15-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28344"},{"key":"bibr16-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.06.2453"},{"key":"bibr17-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.185"},{"key":"bibr18-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.9870"},{"key":"bibr19-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199707000-00011"},{"key":"bibr20-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000240182.61922.31"},{"key":"bibr21-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.1508"},{"key":"bibr22-00034894211021287","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814525747"},{"key":"bibr23-00034894211021287","unstructured":"NCCN Clinical Practice Guidelines in Oncology Head and Neck Cancers. 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