{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:55:14Z","timestamp":1777427714365,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-squamous cell carcinoma sinonasal malignancies (NSCCSM) are relatively rare. Neoadjuvant radiotherapy and\/or chemotherapy (NTx) have been proposed to improve outcomes compared to surgery alone. In this study, we aim to examine the prevalence of NTx utilization and associated outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective study utilizing the National Cancer Database, 2004 to 2015. The study population included adult patients diagnosed with primary NSCCSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 574 patients were included. The mean age of the study population was 61.7\u2009\u00b1\u200916.5\u2009years. The median follow-up time was 40.4\u2009months (interquartile range: 15.3-81.3\u2009months). The histopathological diagnoses identified included: (i) 37.0% adenocarcinoma, (ii) 22.8% adenoid cystic carcinoma, (iii) 20.0% mucosal melanoma, (iv) 11.9% esthesioneuroblastoma, and (v) 8.2% sinonasal undifferentiated carcinoma (SNUC). NTx was utilized in 70 (12.20%) of the study population. Patients who received NTx were more likely to have SNUC or esthesioneuroblastoma ( P\u2009&lt;\u2009.01 each) and to have stage III or IV disease ( P\u2009&lt;\u2009.01 each). NTx was most likely to be administrated in a high-volume center [OR: 3.94, 95%CI: (1.47, 10.53), P\u2009=\u2009.006]. Patients who received NTx had a significantly lower prevalence of positive margin postoperatively [OR: 0.48, 95%CI: (0.26, 0.87), P\u2009=\u2009.016]. In patients with NSCCSM, negative margin was associated with improved overall survival [HR: 0.55, 95%CI: (0.36, 0.82), P\u2009=\u2009.004].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study provides an epidemiological perspective regarding NSCCSM and related practice patterns and survival outcomes. Neoadjuvant radiotherapy and\/or chemotherapy is likely to decrease the risk of positive margin which ultimately could improve survival in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211024783","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T05:43:20Z","timestamp":1623908600000},"page":"420-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Presentation and Outcomes of Non-Squamous Cell Carcinoma Sinonasal Malignancies: A National Perspective"],"prefix":"10.1177","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-7253","authenticated-orcid":false,"given":"Zaid","family":"Al-Qurayshi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarrett E.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"bibr1-00034894211024783","unstructured":"National Cancer Institute, DCCPS, Surveillance Research Program. Surveillance, Epidemiology, and End Results (SEER) program populations (1969\u20132017). 2018. Accessed July 2019. http:\/\/www.seer.cancer.gov\/popdata."},{"key":"bibr2-00034894211024783","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"bibr3-00034894211024783","unstructured":"American College of Surgeons. National cancer database. 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