{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:57:48Z","timestamp":1777427868384,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Selective radiotherapy and concomitant intra-arterial cisplatin infusion (m-RADPLAT) with a lower cisplatin dosage have been performed for organ and function preservation in patients with locally advanced squamous cell carcinoma of the larynx (SCC-L), and results showing a lower rate of adverse events have been reported. This study evaluated the treatment outcomes of patients with T3N0 glottic SCC-L with or without vocal fold fixation (VFF) who were treated with m-RADPLAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed the data of 33 patients with T3N0 SCC-L who received m-RADPLAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The vocal fold in patients with VFF 3\u2009months after completing m-RADPLAT resumed normal movement in 15 patients (83%) and persisted fixation in 3 (17%). The 3-year local control, laryngeal cancer-specific survival, and overall survival rates of patients with or without VFF were 88.9% and 86.7%, 94.1% and 93.3%, and 88.9% and 86.7%, respectively. Additionally, the 3-year freedom from laryngectomy, laryngectomy-free survival, and laryngo-esophageal dysfunction-free survival rates of patients with or without VFF were 94.4% and 86.7%, 88.9% and 73.3%, and 83.3% and 73.3%, respectively. Grade 3 or higher toxicities were observed in all patients: leukopenia in 4 patients (12%), neutropenia in 5 (15%), anemia in 2 (6%), thrombocytopenia in 3 (9%), and mucositis in 2 (6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrated that m-RADPLAT yielded VFF improvement and a favorable survival while maintaining laryngeal function not only in patients with T3N0 glottic SCC-L without VFF but also in patients with VFF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211047789","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T07:17:22Z","timestamp":1632554242000},"page":"897-904","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative Treatment Outcome in T3N0 Glottic Cancer With and Without Vocal Fold Fixation Receiving Radiation Therapy and Concurrent Low-Dose Intra-Arterial Cisplatin Infusion"],"prefix":"10.1177","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-7034","authenticated-orcid":false,"given":"Takeharu","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimitsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-2331","authenticated-orcid":false,"given":"Shun-ichi","family":"Chitose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuichi","family":"Tanoue","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintarou","family":"Sueyoshi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mioko","family":"Fukahori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Muraki","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyoko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuyo","family":"Ogo","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kurume University, Kurume, 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