{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:57:54Z","timestamp":1777427874049,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"national institute for health research","doi-asserted-by":"publisher","award":["NIHR Clinical Doctoral Research Fellowship CDRF-20"],"award-info":[{"award-number":["NIHR Clinical Doctoral Research Fellowship CDRF-20"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Education England"},{"DOI":"10.13039\/501100013342","name":"nihr imperial biomedical research centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To investigate how the symptoms of mucus and cough impact adults living with laryngotracheal stenosis, and to use this information to guide future research and treatment plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A survey was developed with the support of patient advisors and distributed to people suffering with laryngotracheal stenosis. The survey comprised 15 closed and open questions relating to mucus and cough and included the Leicester Cough Questionnaire (LCQ). Descriptive statistics, X\n                      <jats:sup>2<\/jats:sup>\n                      and thematic analyses were completed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 641 participants completed the survey, with 83.62% (n\u2009=\u2009536) reporting problems with mucus; 79% having daily issues of varying severity that led to difficulties with cough (46.18%) and breathing (20.90%). Mucus affected voice and swallowing to a lesser degree. Respondents described a range of triggers; they identified smoky air as the worst environmental trigger. Strategies to manage mucus varied widely with drinking water (72.26%), increasing liquid intake in general (49.35%) and avoiding or reducing dairy (45.32%) the most common approaches to control symptoms. The LCQ showed a median total score of 14 (interquartile range 11-17) indicative of cough negatively affecting quality of life. Thematic analysis of free text responses identified 4 key themes\u2014the Mucus Cycle, Social impact, Psychological impact, and Physical impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study shows the relevance of research focusing on mucus and cough and its negative impact on quality of life, among adults with laryngotracheal stenosis. It demonstrates the inconsistent advice and management strategies provided by clinicians for this issue. Further research is required to identify clearer treatment options and pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211050627","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T08:14:17Z","timestamp":1633680857000},"page":"962-970","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cA Major Quality of Life Issue\u201d: A Survey-Based Analysis of the Experiences of Adults With Laryngotracheal Stenosis with Mucus and Cough"],"prefix":"10.1177","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-731X","authenticated-orcid":false,"given":"Gemma M.","family":"Clunie","sequence":"first","affiliation":[{"name":"Imperial College London, London, UK"},{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Anderson","sequence":"additional","affiliation":[{"name":"Australian Market and Social Research Society, Glebe, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Savage","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Hughes","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin W. G.","family":"Roe","sequence":"additional","affiliation":[{"name":"Imperial College London, London, UK"},{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Imperial College London, London, UK"},{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"McGregor","sequence":"additional","affiliation":[{"name":"Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Imperial College London, London, UK"},{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"bibr1-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24956"},{"key":"bibr2-00034894211050627","unstructured":"Almanzar A, Danckers M. Laryngotracheal Stenosis. StatPearls Publishing; 2021:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554561\/ Available from."},{"key":"bibr3-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2002.11.001"},{"key":"bibr4-00034894211050627","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1872"},{"key":"bibr5-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.06.001"},{"key":"bibr6-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28494"},{"key":"bibr7-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-021-10287-3"},{"key":"bibr8-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418823797"},{"key":"bibr9-00034894211050627","first-page":"399","volume-title":"Laryngology: A Case-Based Approach","author":"Reza Nouraei SA","year":"2019","edition":"1"},{"key":"bibr10-00034894211050627","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17186847"},{"key":"bibr11-00034894211050627","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176341"},{"key":"bibr12-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2015-0013"},{"key":"bibr13-00034894211050627","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2019-0028"},{"key":"bibr14-00034894211050627","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S202580"},{"key":"bibr15-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.339"},{"key":"bibr16-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"bibr17-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"bibr18-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201704-0682IM"},{"key":"bibr19-00034894211050627","unstructured":"BTS\/SIGN. British Guideline on the Management of Asthma. 2019."},{"key":"bibr20-00034894211050627","unstructured":"NICE. Chronic Obstructive Pulmonary Disease in Over 16s: Diagnosis and Management [NG115]. In: NICE, 2019."},{"key":"bibr21-00034894211050627","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320977467"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894211050627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894211050627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894211050627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:34:57Z","timestamp":1777376097000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894211050627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/00034894211050627"],"URL":"https:\/\/doi.org\/10.1177\/00034894211050627","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,8]]}}}