{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:21:06Z","timestamp":1777425666039,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the persistence of human papillomavirus (HPV) infection following treatment of HPV-positive oropharyngeal squamous cell carcinoma (HPV\u2009+\u2009OPSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study was undertaken at The Ottawa Hospital (Ottawa, ON, Canada), a tertiary academic hospital and regional cancer center. Adult patients who were diagnosed with HPV\u2009+\u2009OPSCC between the years of 2014 and 2016 and treated with curative intent, and who were alive and willing to consent were eligible for inclusion. A saliva assay was used to test for the presence of HPV DNA in a random sample of patients. qPCR was used to amplify DNA from saliva samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Saliva samples were obtained from 69 patients previously treated with HPV\u2009+\u2009OPSCC. All patients had a minimum of 2\u2009years of follow-up. 5 patients tested positive for HPV: 2 were positive for HPV-16, 2 for HPV-18, and 1 \u201cother\u201d HPV type. No patient in our study cohort had suffered recurrence post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study is the first to demonstrate the prevalence of persistent oncogenic HPV DNA in saliva following treatment for HPV\u2009+\u2009OPSCC. This prevalence appears to be low, despite the fact that persistent HPV infection is a precursor for the development of HPV\u2009+\u2009OPSCC. This finding raises questions about what factors influence the clearance or persistence of HPV DNA in saliva after treatment for HPV\u2009+\u2009OPSCC, and may add to our understanding about the longitudinal effects of HPV infection in these cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894211055606","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T01:00:13Z","timestamp":1636938013000},"page":"1053-1059","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary HPV Persistence Following Treatment of Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-8917","authenticated-orcid":false,"given":"Alexandra E.","family":"Quimby","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pagona","family":"Lagiou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"},{"name":"School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Purgina","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Corsten","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head & Neck Surgery, Department of Surgery, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Johnson-Obaseki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"key":"bibr1-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"bibr2-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0289"},{"key":"bibr3-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.015"},{"key":"bibr4-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv086"},{"key":"bibr5-00034894211055606","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6526a1"},{"key":"bibr6-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.015"},{"key":"bibr7-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.02.013"},{"key":"bibr8-00034894211055606","doi-asserted-by":"publisher","DOI":"10.3109\/02841860903575307"},{"key":"bibr9-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000136719.42948.5a"},{"key":"bibr10-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"bibr11-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.05.007"},{"key":"bibr12-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.2853"},{"key":"bibr13-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.06.1568"},{"key":"bibr14-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1108489"},{"key":"bibr15-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.0164"},{"key":"bibr16-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08594.x"},{"key":"bibr17-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1126\/science.2537532"},{"key":"bibr18-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318124a4ae"},{"key":"bibr19-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/s1041-892x(07)70241-x"},{"key":"bibr20-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.21.1626"},{"key":"bibr21-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1086\/339193"},{"key":"bibr22-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0179-6"},{"key":"bibr23-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30623"},{"key":"bibr24-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142868"},{"key":"bibr25-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60809-0"},{"key":"bibr26-00034894211055606","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.06.019"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894211055606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894211055606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894211055606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:50Z","timestamp":1777375790000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894211055606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,14]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1177\/00034894211055606"],"URL":"https:\/\/doi.org\/10.1177\/00034894211055606","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,14]]}}}