{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:22:25Z","timestamp":1777425745351,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We report obstructing laryngeal manifestations of Crohn\u2019s disease in a toddler with very early onset-IBD (VEO-IBD) who required tracheotomy tube placement at 27\u2009months of age for relief of recalcitrant airway obstruction unresponsive to maximal medical therapy. We review the literature for the frequency of extra-intestinal laryngeal manifestations of Crohn\u2019s disease in adults and children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Case report and literature review of laryngeal manifestations of Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Laryngeal involvement of Crohn\u2019s disease is very rare with only 14 other cases reported. Most cases appear in adults, with the supraglottis most commonly affected. This case marks the youngest report and only the second report of a patient requiring a tracheotomy for supraglottic obstruction when intensive medical management, including use of steroids and biologics, failed to relieve obstructing laryngeal inflammation. Despite ongoing Crohn\u2019s disease, laryngeal manifestations improved permitting decannulation the following year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Laryngeal manifestations of Crohn\u2019s disease are rare and usually affect adults. Most cases are managed with medical therapy, however surgical excision of obstructing lesions or tracheotomy placement is sometimes required for temporary relief of airway obstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003489421998214","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T04:49:19Z","timestamp":1614833359000},"page":"1202-1206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal Manifestations of Crohn\u2019s Disease in a Toddler with Very Early Onset-IBD"],"prefix":"10.1177","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-5374","authenticated-orcid":false,"given":"Ian A.","family":"Schonman","sequence":"first","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Sehgal","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC, USA"},{"name":"Departments of Gastroenterology, Hepatology and Nutrition (SS) and Otolaryngology Head and Neck Surgery (NMB), Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luv R.","family":"Javia","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Department of Pediatric Otolaryngology and University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-8511","authenticated-orcid":false,"given":"Nancy M.","family":"Bauman","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC, USA"},{"name":"Departments of Gastroenterology, Hepatology and Nutrition (SS) and Otolaryngology Head and Neck Surgery (NMB), Children\u2019s National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"bibr1-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4781-x"},{"key":"bibr2-0003489421998214","volume-title":"Robbins Basic Pathology","author":"Kumar V","year":"2018","edition":"10"},{"key":"bibr3-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.022"},{"key":"bibr4-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000531"},{"key":"bibr5-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800590402"},{"key":"bibr6-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800116"},{"key":"bibr7-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198003000-00013"},{"issue":"5","key":"bibr8-0003489421998214","first-page":"500","volume":"138","author":"Ramsdell WM","year":"1984","journal-title":"Am J Dis Child"},{"key":"bibr9-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.12.1669"},{"key":"bibr10-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100127549"},{"key":"bibr11-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(00)00258-4"},{"key":"bibr12-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1177\/014556130108000208"},{"key":"bibr13-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00098-X"},{"key":"bibr14-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)05280-2"},{"key":"bibr15-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200108"},{"key":"bibr16-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800713"},{"key":"bibr17-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedex.2013.08.004"},{"key":"bibr18-0003489421998214","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.09.021"}],"container-title":["Annals of Otology, Rhinology &amp; 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