{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:23:06Z","timestamp":1777425786150,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Lymphoma, categorized as either non-Hodgkin\u2019s lymphoma or Hodgkin\u2019s lymphoma, is the second most common malignancy in the head and neck. Primary tongue lymphoma is exceedingly rare, with only case reports or small case series in the literature. This population-based analysis is the first to report the epidemiology and prognostic factors of survival in patients with primary tongue lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Surveillance, Epidemiology, and End Results 18 database from the National Cancer Institute was queried for patients diagnosed between the years 2000 and 2016 with tongue lymphoma. Outcomes of interest were overall and disease-specific survival. Independent variables included age at diagnosis, sex, race, marital status, primary subsite, histologic subtype, stage, and treatment type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:<\/jats:title>\n                    <jats:p>Seven hundred forty patients met criteria; the male-female ratio was 1.5:1 and the mean age at diagnosis was 67.8\u2009years. The majority of lesions localized to the base of tongue (90.0%), were histologically diffuse large B-cell lymphoma (59.5%), and presented at stage I or II (77.9%). Most early-stage lymphomas were treated with chemotherapy only (40.5%) or a combination of both chemotherapy and radiation (31.3%), while late-stage cancers were primarily treated with chemotherapy alone (68.5%). In multivariate analysis, younger age at diagnosis, female sex, married\/partnered marital status, mucosa-associated lymphoid tissue histologic subtype, and earlier cancer stage were found to be associated with improved survival. Chemotherapy treatment with or without radiation was also associated with better survival compared to no treatment or radiation alone, though data regarding immunotherapy was unavailable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894221088175","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T06:52:18Z","timestamp":1648882338000},"page":"190-199","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiology and Prognostic Indicators of Survival in Tongue Lymphoma"],"prefix":"10.1177","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-9690","authenticated-orcid":false,"given":"Scott A.","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, St. Louis University Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, St. Louis University Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-7299","authenticated-orcid":false,"given":"Eric Y.","family":"Du","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, St. Louis University Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"bibr1-00034894221088175","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"bibr2-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"bibr3-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.09.020"},{"key":"bibr4-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218218"},{"key":"bibr5-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-1"},{"key":"bibr6-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.8382"},{"key":"bibr7-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850701)56:1<157::aid-cncr2820560125>3.0.co;2-x"},{"key":"bibr8-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802493686"},{"key":"bibr9-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1077"},{"key":"bibr10-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2018.09.055"},{"key":"bibr11-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-018-0210-2"},{"key":"bibr12-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.12.017"},{"key":"bibr13-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01928.x"},{"key":"bibr14-00034894221088175","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.05.007"},{"key":"bibr15-00034894221088175","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program. 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