{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:29:03Z","timestamp":1790702943513,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement","award":["AS 1905702"],"award-info":[{"award-number":["AS 1905702"]}]},{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","award":["110079"],"award-info":[{"award-number":["110079"]}],"id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010799","name":"Stiftelsen Tysta Skolan","doi-asserted-by":"publisher","award":["348"],"award-info":[{"award-number":["348"]}],"id":[{"id":"10.13039\/100010799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Molecular hydrogen (H\n                      <jats:sub>2<\/jats:sub>\n                      ) has shown therapeutic potential in several oxidative stress-related conditions in humans, is well-tolerated, and is easily administered via inhalation.The aim of this preclinical in vivo study was to investigate whether impulse noise trauma can be prevented by H\n                      <jats:sub>2<\/jats:sub>\n                      when inhaled immediately after impulse noise exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Guinea pigs (n\u2009=\u200926) were subjected to impulse noise (n\u2009=\u2009400; 156\u2009dB SPL; 0.33\/s; n\u2009=\u200911; the Noise group), to impulse noise immediately followed by H\n                      <jats:sub>2<\/jats:sub>\n                      inhalation (2\u2009mol%; 500\u2009ml\/min; 1\u2009hour; n\u2009=\u200910; the Noise\u2009+\u2009H\n                      <jats:sub>2<\/jats:sub>\n                      group), or to H\n                      <jats:sub>2<\/jats:sub>\n                      inhalation (n\u2009=\u20095; the H\n                      <jats:sub>2<\/jats:sub>\n                      group). The acoustically evoked ABR threshold at 3.15, 6.30, 12.5, 20.0, and 30.0\u2009kHz was assessed before and 4\u2009days after impulse noise and\/or H\n                      <jats:sub>2<\/jats:sub>\n                      exposure. The cochleae were harvested after the final ABR assessment for quantification of hair cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Noise exposure caused ABR threshold elevations at all frequencies (median 35, 35, 30, 35, and 35\u2009dB SPL, the Noise group; 20, 25, 10, 13, and 20\u2009dB SPL, the Noise\u2009+\u2009H\n                      <jats:sub>2<\/jats:sub>\n                      group; P\u2009&lt;\u2009.05) but significantly less so in the Noise\u2009+\u2009H\n                      <jats:sub>2<\/jats:sub>\n                      group ( P\u2009&lt;\u2009.05). Outer hair cell (OHC) loss was in the apical, mid, and basal regions 8.8%, 53%, and 14% in the Noise group and 3.5%, 22%, and 1.2% in the Noise\u2009+\u2009H\n                      <jats:sub>2<\/jats:sub>\n                      group. The corresponding inner hair cell (IHC) loss was 0.1%, 14%, and 3.5% in the Noise group and 0%, 2.8%, and 0% in the Noise\u2009+\u2009H\n                      <jats:sub>2<\/jats:sub>\n                      group. The difference between the groups was significant in the basal region for OHCs ( P\u2009=\u2009.003) and apical ( P\u2009=\u2009.033) and basal ( P\u2009=\u2009.048) regions for IHCs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Acute acoustic trauma can be reduced by H\n                      <jats:sub>2<\/jats:sub>\n                      when inhaled immediately after impulse noise exposure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894221118764","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:46:56Z","timestamp":1660358816000},"page":"865-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study"],"prefix":"10.1177","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-4660","authenticated-orcid":false,"given":"Pernilla","family":"Videhult Pierre","sequence":"first","affiliation":[{"name":"Division of Audiology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Fransson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden"},{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta A.","family":"Kisiel","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Laurell","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"bibr1-00034894221118764","first-page":"CD006396","volume":"7","author":"Tikka C","year":"2017","journal-title":"Cochrane Database Syst 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