{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:25:37Z","timestamp":1777425937238,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2021-C-075"],"award-info":[{"award-number":["FEMH-2021-C-075"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Fat injection laryngoplasty (FIL) is a common procedure used to correct glottic insufficiency. Nevertheless, few studies have discussed potential treatments for cases with poor voice recovery after FIL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eighteen patients with unfavorable vocal outcomes from FIL were analyzed. Each of these patients presented persistent dysphonia for more than 2\u2009months following FIL, together with bulging vocal folds and poor mucosal wave. We applied microsurgery as the standard treatment to remove excessive fat. Vocal fold steroid injection (VFSI) was administered to patients that were hesitant or declined to undergo microsurgery. Voice outcomes were evaluated using the Voice Handicap Index-10 (VHI-10), grade-roughness-breathiness (GRB) scores, and smoothed cepstral peak prominence (CPPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Six patients underwent microsurgery directly, 6 patients received only VFSIs as a salvage treatment, and the remaining 6 patients received 1 to 3 courses of VFSIs before the decision to undergo microsurgery. Pathology reports were available for 10 patients, and contained 5 instances of adipose tissues, 3 of fat necrosis, 1 of chronic inflammation, and 1 of fibrosis. Seventeen patients reported satisfactory or improved outcomes. We found remarkable improvements in VHI-10, GRB, and CPPs (all P\u2009&lt;\u2009.05) after salvage treatments for FIL. Subgroup analyses showed comparable voice outcomes for patients undergoing direct microsurgery, VFSI alone, and VFSI followed by microsurgery ( P\u2009&gt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrated that fat overinjection and\/or fibrotic change in the injected vocal folds may cause poor voice outcomes after FIL. Both microsurgery and VFSI could be applied as salvage treatments with good voice recovery profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence:<\/jats:title>\n                    <jats:p>Level 4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894221140777","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T01:53:30Z","timestamp":1670896410000},"page":"1200-1205","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Salvage Treatments for Poor Voice Outcomes Following Autologous Fat Injection Laryngoplasty"],"prefix":"10.1177","volume":"132","author":[{"given":"Yu-Hsuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung"},{"name":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei"},{"name":"School of Medicine, Chung Shan Medical University, Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-1291","authenticated-orcid":false,"given":"Chi-Te","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, Taipei"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan"},{"name":"Department of Special Education, University of Taipei, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"bibr1-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199105000-00003"},{"key":"bibr2-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00026"},{"key":"bibr3-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510401109"},{"key":"bibr4-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00027"},{"key":"bibr5-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199702000-00008"},{"key":"bibr6-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199205000-00005"},{"key":"bibr7-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.02.004"},{"key":"bibr8-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0990-z"},{"key":"bibr9-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20529"},{"key":"bibr10-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.180547"},{"key":"bibr11-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-015-0554-0"},{"key":"bibr12-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816654899"},{"key":"bibr13-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.1682"},{"key":"bibr14-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-3303-4_17"},{"key":"bibr15-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22421"},{"key":"bibr16-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200207000-00017"},{"key":"bibr17-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2006.10.003"},{"key":"bibr18-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2008.03.016"},{"key":"bibr19-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.12.001"},{"key":"bibr20-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.09.023"},{"key":"bibr21-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21920"},{"key":"bibr22-00034894221140777","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12909"}],"container-title":["Annals of Otology, Rhinology &amp; 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