{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:00:42Z","timestamp":1792814442848,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective:<\/jats:title>\n To examine the relationship between conferred immunity after standard pneumococcal series and refractory otolaryngologic infections in pediatric patients using post-vaccination antibody titers, and to identify contributory underlying conditions revealed when vaccination\/re-vaccination fails to confer protective immunity.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n \n IRB-reviewed and \u201cexempt\u201d retrospective case series with chart review using the Epic\n \u00ae<\/jats:sup>\n Electronic Medical Record system from 2013 to 2021.\n <\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Dedicated tertiary referral children\u2019s hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Pneumococcal antibody titer results were assessed for children ages 0 to 21\u2009years and: (1) at least 1 of 7 otolaryngologic disease diagnoses and (2) having received the 4-dose schedule of pneumococcal conjugate vaccine (PCV 7 or 13).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 241 subjects met inclusion criteria with 356 laboratory tests. Recurrent acute otitis media, chronic rhinitis, and chronic otitis media with effusion were the 3 most frequent diagnoses. At presentation, only 27.0% of subjects had titers conferring immunity from their prior vaccinations with PCV. About 85 subjects had been subsequently revaccinated with Pneumococcal Polysaccharide Vaccine (PPSV), and antibody responses conferring immunity reached 91.8%. Seven subjects never developed adequate responses; 5 of these had recurrent acute otitis media as the primary otolaryngologic diagnosis. Secondary \u201crevealed\u201d diagnoses included Juvenile Rheumatoid Arthritis (n\u2009=\u20091), unresolved specific antibody deficiency (n\u2009=\u20092), and Hypogammaglobulinemia (n\u2009=\u20091).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In pediatric patients with recurrent infectious otolaryngologic disease refractory to traditional medical and surgical therapy, inadequate responses to pneumococcal vaccination may be revealed. This correlation represents a potential pathway for diagnosis and therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00034894231182745","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T02:30:50Z","timestamp":1688092250000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Non-protective immunity after standard pneumococcal vaccination series identified as a potential contributing risk factor for refractory otolaryngologic conditions in children"],"prefix":"10.1177","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-5159","authenticated-orcid":false,"given":"Caroline A.","family":"Bonaventure","sequence":"first","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2014Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele K.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2014Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA"},{"name":"Children\u2019s Hospital New Orleans, Section of Pediatric Otolaryngology, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"bibr1-00034894231182745","volume-title":"Otolaryngology Head and Neck Surgery Clinical Reference Guide","author":"Pasha R","year":"2022","edition":"6"},{"key":"bibr2-00034894231182745","unstructured":"Gierke R, Wodi AP, Kobayashi M. Pneumococcal disease. Centers for Disease Control and Prevention. 2021, August 18. Accessed January 3, 2022 https:\/\/www.cdc.gov\/vaccines\/pubs\/pinkbook\/pneumo.html#pneumococcal-vaccines"},{"key":"bibr3-00034894231182745","unstructured":"Centers for Disease Control and Prevention. Pneumococcal vaccination: who and when to vaccinate. Centers for Disease Control and Prevention. 2020, August 7. Accessed December 26, 2021 https:\/\/www.cdc.gov\/vaccines\/vpd\/pneumo\/hcp\/who-when-to-vaccinate.html"},{"key":"bibr4-00034894231182745","unstructured":"Centers for Disease Control and Prevention. \u201cAbout pneumococcal vaccine: For providers. Centers for Disease Control and Prevention. August 7, 2020. Accessed December 26, 2021 https:\/\/www.cdc.gov\/vaccines\/vpd\/pneumo\/hcp\/about-vaccine.html"},{"key":"bibr5-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00735-14"},{"key":"bibr6-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198608010-00017"},{"key":"bibr7-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.05.014"},{"key":"bibr8-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074906"},{"key":"bibr9-00034894231182745","first-page":"11","author":"Song CH","year":"2020","journal-title":"Allergy Rhinol"},{"key":"bibr10-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2018.08.002"},{"key":"bibr11-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.021"},{"key":"bibr12-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.002"},{"key":"bibr13-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199609)22:3<167::AID-PPUL5>3.0.CO;2-M"},{"key":"bibr14-00034894231182745","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.Supplement_1.S184"},{"key":"bibr15-00034894231182745","unstructured":"Pneumococcal 7-Valent Conjugate Vaccine (Diphtheria CRM 197 Protein). (package insert). 2018; Accessed June 17, 2023. http:\/\/wayback.archive-it.org\/7993\/20170723031126\/https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/Vaccines\/ApprovedProducts\/UCM137038.pdf"}],"container-title":["Annals of Otology, Rhinology & Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894231182745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894231182745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894231182745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:37Z","timestamp":1777375837000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00034894231182745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,29]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/00034894231182745"],"URL":"https:\/\/doi.org\/10.1177\/00034894231182745","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,29]]}}}