{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:19:15Z","timestamp":1787163555360,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Chronic refractory cough is defined as cough lasting greater than 8\u2009weeks and with an unclear etiology. Blockade of the internal branch superior laryngeal nerve (iSLN) has been shown to be safe and effective in the treatment of chronic cough. It remains unknown, however, if underlying comorbidities impact patient response to iSLN blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 44 patients aged 18\u2009years and older were seen at our institution\u2019s Laryngology clinics between 2019 and 2022 and treated with iSLN blockade. Patient demographics, comorbidities, and pre- and post-treatment cough severity index (CSI) scores were collected from electronic medical records. Two-tailed independent T tests were used to compare CSI scores between groups with and without 4 underlying comorbidities: GERD, pulmonary history, smoking history, and evidence of vocal fold paresis or asymmetry on stroboscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients with a history of GERD or smoking and those with evidence of glottic insufficiency had similar improvements in CSI compared to those who did not (22.5\u2009\u00b1\u200926.4 vs 45.0\u2009\u00b1\u200947.1, P\u2009=\u2009.36; 32.7\u2009\u00b1\u200927.8 vs 29.0\u2009\u00b1\u200938, P\u2009=\u2009.85; 41.3\u2009\u00b1\u200918.8 vs 27.2\u2009\u00b1\u200937.7, P\u2009=\u2009.195). Patients with underlying pulmonary conditions had a significantly reduced response to iSLN blockade than did patients without underlying disease (9.85\u2009\u00b1\u200915.0 vs 47.4\u2009\u00b1\u200938.1, P\u2009=\u2009.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Underlying lung pathology may contribute to decreased iSLN blockade efficacy in the treatment of chronic refractory cough from laryngeal hypersensitivity and its treatment is likely necessary for optimal symptom reduction. Characterizing patient comorbidity profiles can help guide patient counseling on expected treatment efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894241231375","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:46:55Z","timestamp":1708408015000},"page":"519-523","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Medical Comorbidities on Cough Improvement Following Superior Laryngeal Block"],"prefix":"10.1177","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2740-7516","authenticated-orcid":false,"given":"Rema","family":"Shah","sequence":"first","affiliation":[{"name":"Yale University School of Medicine, New Haven, CT, USA"},{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, New Haven, CT, USA"},{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devesh","family":"Malik","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, New Haven, CT, USA"},{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Kohli","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, New Haven, CT, USA"},{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"bibr1-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25186"},{"key":"bibr2-00034894241231375","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:123251"},{"key":"bibr3-00034894241231375","unstructured":"Clinical Pulmonary. About CHEST Guidelines. American College of Chest Physicians. Accessed April 17, 2023. https:\/\/www.chestnet.org\/guidelines\/clinical-pulmonary"},{"key":"bibr4-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00370-w"},{"key":"bibr5-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1496"},{"key":"bibr6-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9701-2"},{"key":"bibr7-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1044\/2022_AJSLP-21-00364"},{"key":"bibr8-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.292"},{"key":"bibr9-00034894241231375","unstructured":"Soriano RM, Winters R, Gupta V. Anatomy, Head | Neck: Larynx Nerves. StatPearls Publishing. 2022. Accessed April 1, 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557742\/"},{"key":"bibr10-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60776-4"},{"key":"bibr11-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.10.004"},{"key":"bibr12-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013067.pub2"},{"key":"bibr13-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.11.017"},{"key":"bibr14-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27201"},{"key":"bibr15-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29585"},{"key":"bibr16-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30570"},{"key":"bibr17-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13857"},{"key":"bibr18-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X21994468"},{"key":"bibr19-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60595-4"},{"key":"bibr20-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1186\/2049-6958-7-5"},{"key":"bibr21-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12366"},{"key":"bibr22-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01845-2"},{"key":"bibr23-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1843CI"},{"key":"bibr24-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9188-9"},{"key":"bibr25-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00007806"},{"key":"bibr26-00034894241231375","volume":"30","author":"Gaynor EB.","year":"2000","journal-title":"J Clin Gastroenterol"},{"key":"bibr27-00034894241231375","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.10.007"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241231375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894241231375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241231375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:45Z","timestamp":1777375845000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894241231375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/00034894241231375"],"URL":"https:\/\/doi.org\/10.1177\/00034894241231375","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}