{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:30:34Z","timestamp":1777426234657,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Research Project of Zhejiang Chinese Medical University","award":["2022FSYYZQ04"],"award-info":[{"award-number":["2022FSYYZQ04"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171157"],"award-info":[{"award-number":["82171157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Traditional Chinese Medicine of Zhejiang Province Science and Technology plan project","award":["2022ZQ041"],"award-info":[{"award-number":["2022ZQ041"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"\n Objectives:<\/jats:title>\n Ixekizumab, an interleukin (IL)-17A inhibitor, exerts its therapeutic effects in psoriasis by inhibiting the interleukin (IL)-17 signaling pathway. Common adverse reactions to ixekizumab include injection site reactions and upper respiratory tract infections (URIs), while occurrences of inflammatory bowel disease (IBD) and multiple mucosal ulcers are infrequent. We present a case of a 51-year-old man who developed multiple mucosal ulcers after ixekizumab treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A 51-year-old man presented to our hospital with a 1-month history of pharyngalgia. The flexible laryngoscope displayed mild hyperemia in the pharyngeal mucosa and tonsils, redness and swelling of the epiglottis, as well as multiple ulcers in the oral cavity, uvula, and epiglottis. These ulcers did not improve with conventional treatment.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Upon evaluation, the ulcers were an immune-related adverse event induced by ixekizumab. Consequently, a decision was made to discontinue the drug and initiate a therapeutic regimen including corticosteroids and thalidomide. Eventually, the patient\u2019s symptoms abated.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Biologics are now becoming increasingly popular in psoriasis. It is vital for clinicians to be aware of this potential adverse event and to identify and intervene early to alleviate patients\u2019 suffering.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00034894241254431","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:58:05Z","timestamp":1715669885000},"page":"750-754","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Mucosal Ulcers Induced by Ixekizumab: A Case Report"],"prefix":"10.1177","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3991-6708","authenticated-orcid":false,"given":"Cheng","family":"Zheng","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"He","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuxia","family":"Tang","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"bibr1-00034894241254431","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2020.1729736"},{"key":"bibr2-00034894241254431","volume":"9","author":"Ward M","year":"2021","journal-title":"SAGE Open Med Case Rep"},{"key":"bibr3-00034894241254431","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002435"},{"key":"bibr4-00034894241254431","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02489.x"},{"issue":"12","key":"bibr5-00034894241254431","first-page":"1327","volume":"128","author":"Macario-Barrel A","year":"2001","journal-title":"Ann Dermatol Venereol"}],"container-title":["Annals of Otology, Rhinology & Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241254431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894241254431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241254431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:50Z","timestamp":1777375850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894241254431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1177\/00034894241254431"],"URL":"https:\/\/doi.org\/10.1177\/00034894241254431","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]}}}