{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:31:25Z","timestamp":1777426285701,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Oral corticosteroids (OCS) are frequently prescribed by otolaryngologists. However, there are limited quantitative data on OCS-related adverse events (AEs) in otolaryngology. We sought to quantify OCS-related AEs in otolaryngology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All outpatient otolaryngology encounters in our healthcare system (2018-2023) at which an OCS was prescribed were identified via the electronic medical record. The diagnoses indicating OCS were categorized as sinonasal, otologic, pharyngo-laryngeal, and other. The medical record was subsequently examined to assess for OCS AEs during the 21-day period following the prescription. OCS AEs were grouped into (1) gastrointestinal, (2) metabolic, (3) bone\/muscle, (4) ophthalmologic, and\/or (5) psychiatric complications. The frequency and types of OCS related AEs were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 20\u2009746 otolaryngology encounters with OCS prescribed were examined. Seventy OCS courses had 1 or more AEs, implying a number needed to harm of 296.4 (240.2-386.8). There were 83 total OCS-related AEs, yielding an AE incidence rate of 4.0:1000 (95% CI, 3.0-5.0:1000) OCS prescriptions. The mean age of subjects with AEs (61.5\u2009years) was significantly higher than those without (50.3\u2009years; P\u2009&lt;\u2009.001). Forty-seven (56.6%) of the complications were metabolic, with hyperglycemia and hypokalemia the most common, followed by gastrointestinal (26.5%), ophthalmologic (3.6%), psychiatric (2.4%), and musculoskeletal (2.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AEs related to OCS prescribed by otolaryngologists occur at a rate of once per 296 courses of treatment and older populations may be at increased risk for AEs. Otolaryngologists should balance AE rates against anticipated benefits of steroid therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence:<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894241282577","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T01:24:28Z","timestamp":1727227468000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Complications of Oral Corticosteroid Use in Otolaryngology"],"prefix":"10.1177","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-7670","authenticated-orcid":false,"given":"Margaret B.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Otolaryngology, Massachusetts Eye & Ear, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan D.","family":"Workman","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Otolaryngology, Massachusetts Eye & Ear, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-5824","authenticated-orcid":false,"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Department of Otolaryngology, Massachusetts Eye & Ear, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"bibr1-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221087664"},{"key":"bibr2-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859885"},{"key":"bibr3-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1177\/00034894211026737"},{"key":"bibr4-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1415"},{"key":"bibr5-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.04.003"},{"key":"bibr6-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24556"},{"key":"bibr7-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810390470"},{"key":"bibr8-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21016"},{"key":"bibr9-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201904-0903SO"},{"key":"bibr10-00034894241282577","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S176026"},{"key":"bibr11-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.046"},{"key":"bibr12-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21072"},{"key":"bibr13-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.018"},{"key":"bibr14-00034894241282577","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.01.003"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241282577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894241282577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894241282577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:30:56Z","timestamp":1777375856000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894241282577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/00034894241282577"],"URL":"https:\/\/doi.org\/10.1177\/00034894241282577","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}