{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:31:52Z","timestamp":1777426312121,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The endoscopic endonasal approach (EEA) has become the preferred treatment for pituitary tumors, with minimal sinonasal morbidity. However, patients with Cushing\u2019s disease (CD) may represent a subgroup with prolonged impairment of sinonasal quality of life (QOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively identified patients with CD who underwent EEA at our institution. Control patients with non-functional tumors were matched by age, gender, and extent of EEA. The primary outcome was post-operative 22-item Sino-Nasal Outcome Test (SNOT-22) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ten patients with CD met the selection criteria and 20 controls were selected for comparison. Nine of the CD patients achieved persistent endocrinologic remission post-operatively. Comparing the CD and control groups, there was no difference in post-operative SNOT-22 score at 1 or 3\u2009months. At 6\u2009months, SNOT-22 scores were significantly worse in the CD group (27.4\u2009\u00b1\u200921.6 vs. 2.8\u2009\u00b1\u20092.3, P\u2009=\u2009.039). SNOT-22 scores improved to normal from 1 to 6\u2009months in the control cohort ( P\u2009=\u2009.007), but not in the Cushing\u2019s group ( P\u2009=\u2009.726). Morbidity was present across all SNOT-22 domains, but was highest in the sleep domain ( P\u2009=\u2009.023). Only morbidity in the facial domain improved over time ( P\u2009=\u2009.032).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with CD have significantly prolonged postoperative sinonasal QOL impairment following EEA compared to patients with non-functioning tumors, who normalize within 6\u2009months. In CD patients, only morbidity in the facial domain, likely related to post-operative pain and nasal packing, improved over time, while the sleep domain was the most affected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894241290978","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T12:29:42Z","timestamp":1729340982000},"page":"42-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sinonasal Outcomes after Endoscopic Pituitary Surgery in Patients With Cushing\u2019s Disease"],"prefix":"10.1177","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-2273","authenticated-orcid":false,"given":"Nadeem R.","family":"Kolia","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Cooper University Health Care, Camden, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara M.","family":"Fleseriu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhanudh","family":"Thavaraputta","sequence":"additional","affiliation":[{"name":"Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouneh K.","family":"Fazeli","sequence":"additional","affiliation":[{"name":"Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-4522","authenticated-orcid":false,"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"bibr1-00034894241290978","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.07.065"},{"key":"bibr2-00034894241290978","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22326"},{"key":"bibr3-00034894241290978","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22398"},{"key":"bibr4-00034894241290978","doi-asserted-by":"publisher","DOI":"10.1007\/bf03345431"},{"key":"bibr5-00034894241290978","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5541"},{"key":"bibr6-00034894241290978","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00227"},{"issue":"6","key":"bibr7-00034894241290978","first-page":"1082","volume":"116","author":"Gordon 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