{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:31:02Z","timestamp":1777426262367,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Soluble fibrinogen-like protein 2 (sFGL2) may be involved in the pathology and progression of allergic rhinitis (AR) through regulating T-helper (Th)2 cell response. This study aimed to explore the ability of sFGL2 to estimate outcomes in AR patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>sFGL2 was detected in the serum sample of 119 AR patients at baseline and 20 healthy controls (HCs) after enrollment by enzyme-linked immunosorbent assay. In AR patients, disease severity was assessed at baseline as well as 4\u2009weeks (W4) and 8\u2009weeks (W8) after enrollment by the total nasal symptom score (TNSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      sFGL2 was higher in AR patients than HCs [median (interquartile range): 100.0 (70.0-154.0) vs 47.0 (31.5-78.5) ng\/mL] (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In AR patients, sFGL2 was positively correlated with TNSS score (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002), itching score (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.037), sneezing score (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.012), and interleukin (IL)-4 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.006) at baseline. TNSS score declined from baseline to W8 in AR patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). To further explore the association between sFGL2 levels and treatment outcomes, we compared the sFGL2 levels between patients with TNSS scores at W4 or W8 &gt;4 and those with TNSS scores at W4 or W8 \u22644. It was found that sFGL2 was only increased in AR patients with a TNSS score at W4 &gt;4 versus those with a TNSS score at W4 \u22644 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum sFGL2 is increased in AR patients, and its high level estimates an increased Th2 cytokine and disease severity as well as poor outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894241304931","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:18:19Z","timestamp":1734405499000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Soluble Fibrinogen-Like Protein 2 Estimates Increased T-Helper 2 Cytokine, Elevated Disease Severity, and Unfavorable Outcomes in Allergic Rhinitis Patients"],"prefix":"10.1177","volume":"134","author":[{"given":"Xiaoqiong","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1533-5415","authenticated-orcid":false,"given":"Song","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12130"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0530"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15454"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.01.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23090"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2023.2225770"},{"issue":"5","key":"e_1_3_3_8_2","first-page":"466","article-title":"Allergic rhinitis: rapid evidence review","volume":"107","author":"Weaver-Agostoni J","year":"2023","unstructured":"Weaver-Agostoni J, Kosak Z, Bartlett S. 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