{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:15Z","timestamp":1777426335012,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The prevalence of obstructive sleep apnea (OSA) is known to be higher in children with Down syndrome (DS) than the general pediatric population, with lower rates of surgical cure. This study aims to determine the prevalence and predictors of OSA and evaluate the outcomes of surgical intervention for OSA in a cohort of Australian children with DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted on 156 patients with DS from 0 to 18\u2009years who had undergone overnight, attended polysomnography (PSG) at Sydney Children\u2019s Hospital from January 2010 to July 2023. Logistic regression was used to assess associations between OSA and age, gender, body mass index (BMI), and tonsillar size. The outcomes of surgery were determined by comparing the pre-operative and post-operative PSG results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevalence of OSA at first PSG was 65.8%, defined by an obstructive apnea-hypopnea index (OAHI) \u22651 event\/hour. Elevated BMI in children above 2\u2009years was associated with the presence of OSA (odds ratio [OR]\u2009=\u20091.32; 95% confidence interval [CI]\u2009=\u20091.02-1.71). Male gender was a predictor for an OAHI &gt;5 events\/hour (OR\u2009=\u20094.01, 95% CI\u2009=\u20091.09-14.78). Among 35 patients who underwent adenotonsillectomy and had a valid pre-operative and post-operative PSG, median OAHI was reduced from 12.6 to 3.8 events\/hour (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002). In 13 patients who had secondary upper airway surgery, median OAHI was reduced from 8.5 to 2.6 events\/hour (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.075).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Children with DS and OSA who undergo surgical intervention may experience improvements to their PSG parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894241309213","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T02:12:47Z","timestamp":1735956767000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgery for Obstructive Sleep Apnea in Children With Down Syndrome in an Australian Population"],"prefix":"10.1177","volume":"134","author":[{"given":"Rebecca","family":"Kim","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Women\u2019s Health Paediatrics and Child Health, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Teng","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Women\u2019s Health Paediatrics and Child Health, University of New South Wales, Sydney, NSW, Australia"},{"name":"Department of Sleep Medicine, Sydney Children\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-4648","authenticated-orcid":false,"given":"Marlene","family":"Soma","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Women\u2019s Health Paediatrics and Child Health, University of New South Wales, Sydney, NSW, Australia"},{"name":"Department of Otolaryngology, Sydney Children\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/nss.S154723"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/children8111074"},{"key":"e_1_3_3_4_2","volume-title":"StatPearls","author":"Akhtar F","year":"2024","unstructured":"Akhtar F, Bokhari SRA. 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