{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:45Z","timestamp":1791330945946,"version":"4.3.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate and compare the treatment outcomes of using topical steroids combined with antibiotics versus growth factor concentrate in type 1 tympanoplasty for chronic otitis media (mucosal type) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study comprised patients with chronic otitis media mucosal type, who underwent type 1 tympanoplasty. Sixty six patients were randomly divided into 3 groups, each consisting of 33 patients. In Group A, topical steroids and antibiotics were used during the procedure, while in Group B, a growth factor concentrate was used. The outcomes were assessed through postoperative otoendoscopy and air bone gap at the end of the 1st and 3rd\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In this study, Group A (patients who underwent type 1 tympanoplasty with topical steroids and antibiotics) had a 12.1% rate of residual perforation and an 18.2% rate of reperforation after 3\u2009months. In contrast, Group B (patients treated with growth factor concentrate) had significantly lower rates of both residual perforation (3%) and reperforation (3%). While the postoperative air-bone gap at the end of the 3rd\u2009month improved in Group B (13.58\u2009\u00b1\u20093.21\u2009dB) compared to Group A (15.45\u2009\u00b1\u20095.11\u2009dB), the difference was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Growth factor concentrate has shown better graft uptake than topical antibiotics and steroids, making it a promising treatment option for augmenting tympanic membrane repair. Its biocompatibility leads to more consistent outcomes, improving patient satisfaction, and supporting broader use in otologic surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894251362511","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:46:16Z","timestamp":1755582376000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cImpact of Growth Factor Concentrate Versus Topical Steriods With Antibiotics in Type 1 Tympanoplasty\u201d"],"prefix":"10.1177","volume":"135","author":[{"given":"Rashmitha","family":"Gowdlar Malleshappa","sequence":"first","affiliation":[{"name":"Department of ENT, Sri Venkateshwara ENT Institute, Bangalore Medical College and Research Institute, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya B.","family":"Thimmaiah","sequence":"additional","affiliation":[{"name":"Department of ENT, Sri Venkateshwara ENT Institute, Bangalore Medical College and Research Institute, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopashri","family":"Tarikere Jayaram","sequence":"additional","affiliation":[{"name":"Department of ENT, Sri Venkateshwara ENT Institute, Bangalore Medical College and Research Institute, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-4566","authenticated-orcid":false,"given":"Anil Kumar","family":"Ramabhadraiah","sequence":"additional","affiliation":[{"name":"Department of ENT, Sri Venkateshwara ENT Institute, Bangalore Medical College and Research Institute, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. Chronic suppurative otitis media: burden of illness and management options. In: Chronic suppurative otitis media: burden of illness and management options; 2004."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","DOI":"10.1201\/9780203731000","volume-title":"Scott-Brown\u2019s Otorhi-nolaryngology and Head and Neck Surgery: Volume 1: Basic Sciences, Endocrine Surgery, Rhinology","author":"Watkinson JC","year":"2018","unstructured":"Watkinson JC, Clarke RW, eds. Scott-Brown\u2019s Otorhi-nolaryngology and Head and Neck Surgery: Volume 1: Basic Sciences, Endocrine Surgery, Rhinology. CRC Press; 2018."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119002391"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20223341"},{"key":"e_1_3_3_6_2","first-page":"10","article-title":"Clinical and trichoscopic analysis of PRP versus GFC used for male and female pattern hair loss","volume":"2022","author":"Garg S","unstructured":"Garg S, Thirumalaiswamy A. Clinical and trichoscopic analysis of PRP versus GFC used for male and female pattern hair loss. Dermatol Surg. 2022:10-97.","journal-title":"Dermatol Surg"},{"key":"e_1_3_3_7_2","article-title":"Surgery of the ear. Shelton, conn.: People\u2019s medical publ","volume":"2010","author":"Gulya AJ","unstructured":"Gulya AJ, Minor LB, Poe DS. Surgery of the ear. Shelton, conn.: People\u2019s medical publ. House. 2010:447-120.","journal-title":"House"},{"key":"e_1_3_3_8_2","volume-title":"Platelet-Rich Plasma. Lecture Notes in Bioengineering","author":"Textor J","unstructured":"Textor J. Platelet-Rich Plasma (PRP) as a therapeutic agent: platelet biology, growth factors and a review of the literature. In: Lana J, Andrade Santana M, Dias Belangero W, Malheiros Luzo A, eds. Platelet-Rich Plasma. Lecture Notes in Bioengineering. Springer."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59071292"},{"issue":"1","key":"e_1_3_3_10_2","article-title":"The impact of topical application of platelet-rich fibrin on graft survival in surgeries for chronic otitis media","volume":"16","author":"Saini S","year":"2024","unstructured":"Saini S, Khan SR, Kumar MB, Singh K, Pandey P. The impact of topical application of platelet-rich fibrin on graft survival in surgeries for chronic otitis media. Cureus. 2024;16(1):e53202.","journal-title":"Cureus"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2015.02.016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_369_19"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_750_20"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2023.10.001"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894251362511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894251362511","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894251362511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:31:26Z","timestamp":1777375886000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894251362511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/00034894251362511"],"URL":"https:\/\/doi.org\/10.1177\/00034894251362511","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]}}}