{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:19:04Z","timestamp":1777868344702,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aims to compare the accuracy of the TUNE, American Speech-Language-Hearing Association (ASHA), and Common Terminology Criteria for Adverse Events (CTCAE) grading systems in reflecting the severity of treatment-related hearing loss, as measured by pure-tone audiometry and patient-reported hearing loss using the Speech, Spatial, and Qualities of Hearing scale compare questionnaire (SSQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study is a prospective, multicenter, cross-sectional, and observational study from 2018 to 2024 conducted at the Netherlands Cancer Institute - Antoni van Leeuwenhoek Amsterdam, Leiden University Medical Center, and University Medical Center Utrecht. In this trial, 109 patients with an indication for curative platinum-based chemotherapy (dose\u2009\u2265\u2009200\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were included, of whom 74 were eligible for analysis. Standard frequency and extended high-frequency pure tone audiometry were measured at baseline and follow-up. The SSQ was administered at follow-up to assess patient-reported outcome measures for hearing loss. The TUNE, ASHA, and CTCAE criteria were derived from audiometry. Concordance and Spearman\u2019s correlations were evaluated between all 3 grading systems and the SSQ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      \u2009The concordance of TUNE with the SSQ was 81%. The concordance of CTCAE and ASHA with the SSQ was 73% and 68%, respectively. A statistically significant Spearman\u2019s correlation coefficient of \u2212.35 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01) was found between TUNE and the SSQ. The Spearman\u2019s correlation coefficient with CTCAE or ASHA and SSQ was \u2212.10 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.10) and .04 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.75), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study found that the TUNE is better in reflecting platinum-related patient-reported hearing loss compared to the CTCAE and ASHA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894251408705","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:17:21Z","timestamp":1768796241000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Multicenter Observational Study Investigating the Concordance Between Patient-Reported Hearing Loss and Commonly Used Ototoxicity Grading Systems in Patients Treated with Platinum-Based Chemotherapy"],"prefix":"10.1177","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-3981","authenticated-orcid":false,"given":"Anouk V. M.","family":"Burger","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"},{"name":"Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte W.","family":"Duinkerken","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands"},{"name":"Department of Otolaryngology, Haaglanden Medical Center, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonoor A. R.","family":"Theunissen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Reinier de Graaf Hospital, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk W. M. A.","family":"Schaeffers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hauptmann","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander E.","family":"Hoetink","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons J. M.","family":"Balm","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Paul","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Maas-Bannink","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Exterkate","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije","family":"Slingerland","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center, Leiden University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen C.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Stokroos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remco","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lot A.","family":"Devriese","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter A.","family":"Dreschler","sequence":"additional","affiliation":[{"name":"Department of Audiology, Amsterdam University Medical Center, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjasse D.","family":"Bruintjes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands"},{"name":"Apeldoorn Dizziness Centre, Gelre Hospital Apeldoorn, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaske E.","family":"van Sluis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte L.","family":"Zuur","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands"},{"name":"Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy133"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1809394"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics3030268"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.09.015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.06.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.603"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.8822"},{"key":"e_1_3_3_11_2","unstructured":"Common terminology criteria for adverse events (ctcae) version 5. 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