{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:14:23Z","timestamp":1783422863324,"version":"3.54.6"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n Objective:<\/jats:title>\n To investigate the relationship between frailty and steroid treatment outcomes in patients with sudden sensorineural hearing loss (SSNHL).<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n Retrospective cohort study<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Tertiary-care institution.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n 185 adult patients (\u226519\u2009years) with unilateral SSNHL presenting January 1, 2017 to May 24, 2023, stratified by 5-Factor Modified Frailty Index (mFI5).<\/jats:p>\n <\/jats:sec>\n \n Interventions:<\/jats:title>\n Oral prednisone and\/or intratympanic dexamethasone.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures:<\/jats:title>\n Post-treatment changes in pure-tone average (PTA), speech reception threshold (SRT), and word recognition scores (WRS).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Female and younger patients were significantly less frail than male and older patients (\n P<\/jats:italic>\n \u2009=\u2009.004,\n P<\/jats:italic>\n \u2009<\u2009.001 respectively). Patients with higher frailty scores (\u22652) were less likely to receive oral steroids (59.6% vs 82.8%,\n P<\/jats:italic>\n \u2009=\u2009.004), though equally likely to receive intratympanic steroids (\n P<\/jats:italic>\n \u2009=\u20091.000). However, patients classified as frail (\u22651) were not more likely to receive intratympanic steroids alone compared to combination therapy (\n P<\/jats:italic>\n \u2009=\u2009.220). Higher frailty scores were significantly associated with metabolic syndrome (\n P<\/jats:italic>\n \u2009=\u2009.002), but specific treatment patterns in diabetic patients could not be delineated as treatment was individualized. Dizziness (\n P<\/jats:italic>\n \u2009=\u2009.650) and vertigo (\n P<\/jats:italic>\n \u2009=\u2009.200) did not correlate with frailty or treatment outcomes. The number of comorbidities increased with higher frailty scores (\n P<\/jats:italic>\n \u2009<\u2009.001) but did not directly correlate with SSNHL outcomes. No significant differences were observed in audiometric outcomes (PTA\/SRT\/WRS) based on patient frailty scores across all comparisons (\n P<\/jats:italic>\n \u2019s\u2009>\u2009.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n While we found an association between frailty scores and treatment selection for SSNHL, we did not find a significant association between frailty scores and treatment outcomes. Therefore, treatment may be individualized in frail patients without compromising audiometric outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00034894261435264","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T12:08:41Z","timestamp":1776600521000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Frailty and Steroid Treatment Outcomes in Patients with Sudden Sensorineural Hearing Loss"],"prefix":"10.1177","volume":"135","author":[{"given":"Lina M.","family":"Adwer","sequence":"first","affiliation":[{"name":"College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Lyden","sequence":"additional","affiliation":[{"name":"College of Public Health, University of Nebraska Medical Center, Omaha, NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-2552","authenticated-orcid":false,"given":"Anne K.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199611000-00008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000222"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1641218"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859885"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003422.pub4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02722-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003134820952438"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003933"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003717"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812458401"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000004389"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.09.011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.102985"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.07.005"}],"container-title":["Annals of Otology, Rhinology & Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894261435264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00034894261435264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00034894261435264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:21:06Z","timestamp":1783419666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00034894261435264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,19]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/00034894261435264"],"URL":"https:\/\/doi.org\/10.1177\/00034894261435264","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,19]]}}}