{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:14:16Z","timestamp":1788257656973,"version":"build-2803163510"},"reference-count":56,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the efficacy of adjuvant MMC in the endoscopic treatment of airway stenoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources:<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE, Cochrane Library, Scopus, Embase, and Google Scholar databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review methods:<\/jats:title>\n                    <jats:p>A literature search was conducted following PRISMA guidelines. The PICOS tool was used to determine the eligibility criteria for this study. A single arm meta-analysis was performed for stenosis resolution, the rate of patients requiring multiple endoscopic procedures, and the rate of patients requiring other surgical treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total number of 358 patients (median age: 48.0\u2009years; 95% CI 44.8-50.8) were included. The median follow-up was 25.2\u2009months (n\u2009=\u2009244\/358; 95% CI 15.4-38.3). Overall, the cumulative stenosis resolution rate was 76.37% (n\u2009=\u2009187\/254; 95% CI 59.72-89.64), the rate of patients requiring multiple endoscopic procedures was 52.33% (n\u2009=\u2009131\/260; 95% CI 32.03-72.25), and the rate of patients requiring other surgical treatments was 4.08% (n\u2009=\u200926\/310; 95% CI 0.37-11.48). The median intervention-free interval was 366\u2009days (n\u2009=\u2009155\/358; 95% CI 270-696).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Current evidence does not allow definitive conclusions regarding the efficacy of adjuvant MMC in reducing recurrence or prolonging intervention-free intervals in airway stenosis. Further well-designed prospective studies are needed to clarify the role of MMC and to inform evidence-based guidelines for patient selection and treatment use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence:<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00034894261449765","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:00:26Z","timestamp":1778673626000},"page":"760-772","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitomycin C in the Endoscopic Treatment of Airway Stenosis: A Systematic Review and a Meta-Analysis"],"prefix":"10.1177","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-0727","authenticated-orcid":false,"given":"Elena","family":"Russo","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Sense Organs, \u2018Sapienza\u2019 University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mangiameli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cariboni","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Maria","family":"Festa","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Alloisio","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marulli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Maria","family":"Ferraroli","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"De Virgilio","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Sense Organs, \u2018Sapienza\u2019 University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1052-3359(03)00002-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198510000-00015"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100412"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600609"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200417"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197903000-00016"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppnen.2013.10.003"},{"key":"e_1_3_2_9_2","first-page":"141","article-title":"Mitomycin, a new antibiotic from streptomyces","volume":"9","author":"Hata T","year":"1956","unstructured":"Hata T, Sano Y, Sugawara R, et al. 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