{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:32:32Z","timestamp":1793341952088,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"\n Background:<\/jats:title>\n Esophageal squamous papilloma (ESP) is a rare, benign, often asymptomatic lesion of the upper aerodigestive tract. While historically managed by gastroenterologists, transnasal esophagoscopy has been incorporated into some otolaryngology practices, expanding the role of the otolaryngologist in diagnosing these lesions.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To describe a case series of ESP within a tertiary dysphagia center and evaluate the association between human papillomavirus (HPV) and chronic mucosal irritation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective case series was conducted of all individuals diagnosed with ESP at a tertiary center over a 2-year period. Histopathology and DNA in-situ hybridization (ISH) for high and low-risk HPV were reviewed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Five cases were identified. All patients presented with dysphagia or heartburn. ESP was an incidental finding in all cases, co-existing with cricopharyngeal dysfunction, hiatal hernia, or esophagitis. One patient had a history of HPV+ oropharyngeal carcinoma. All lesions were successfully resected endoscopically. ISH was negative for HPV in all specimens.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Significance:<\/jats:title>\n ESP is a benign entity frequently encountered incidentally during the workup of dysphagia. These results support chronic irritation rather than HPV as the primary etiology. Recognition is vital for otolaryngologists to ensure appropriate resection and surveillance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00034894261473345","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:42:21Z","timestamp":1785145341000},"page":"954-958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Esophageal Squamous Papilloma in the Practice of Otolaryngology: A Case Series and Diagnostic Considerations for the otolaryngologist"],"prefix":"10.1177","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-4647","authenticated-orcid":false,"given":"Yuval","family":"Nachalon","sequence":"first","affiliation":[{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nogah","family":"Nativ-Zeltzer","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical & Health Sciences, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt B.","family":"Schaberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Belafsky","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02531.x"},{"issue":"2","key":"e_1_3_3_3_2","first-page":"191","article-title":"A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies","volume":"6","author":"Terada T.","year":"2013","unstructured":"Terada T. A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies. 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Human papillomavirus tumor infection in esophageal squamous cell carcinoma. J Gastrointest Oncol. 2015;6(3):287-295.","journal-title":"J Gastrointest Oncol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/659820"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2018.058"},{"issue":"2","key":"e_1_3_3_18_2","article-title":"Prevalence of esophageal squamous papilloma (ESP) and associated cancer in northeastern France","volume":"3","author":"d\u2019Huart MC","year":"2015","unstructured":"d\u2019Huart MC, Chevaux JB, Bressenot AM, et al. Prevalence of esophageal squamous papilloma (ESP) and associated cancer in northeastern France. 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