{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:00:19Z","timestamp":1777424419231,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1973,7,1]],"date-time":"1973-07-01T00:00:00Z","timestamp":110332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[1973,7]]},"abstract":"<jats:p>\n                    Sodium fluoride (NaFl) has the effect of changing active foci of otosclerosis to quiescence. Strontium\n                    <jats:sup>85<\/jats:sup>\n                    (Sr\n                    <jats:sup>85<\/jats:sup>\n                    ) was used to determine the process of calcium deposition in normal canal wall bone and in the footplates of patients with bilateral otosclerosis before and after the administration of NaFl. The first surgery was performed on the poorer hearing ear. Fragments from oval window bone initially showed up to 34 times as much radioactivity as fragments from canal wall bone. The patients then took 25 mg of NaFl daily for six months. None failed to close and maintain gap closure within 11 dB for five months. The same evaluation was done on the bone of the footplate after surgery on the second ear. There was little or no more radioactivity in the footplate bone than in the ear canal wall bone used as a control, indicating cessation or diminution of activity at the otosclerotic focus. Prior to initiating this study, other patients with familial, progressive, purely sensorineural loss showed little or no hearing loss progression after undergoing fluoride therapy. We now recommend 25 mg daily for individuals with progressive hereditary sensorineural hearing loss and evidence of otosclerosis by polytomography.\n                  <\/jats:p>","DOI":"10.1177\/000348947308200417","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:29:51Z","timestamp":1412346591000},"page":"609-615","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Sodium Fluoride on Otosclerotic Activity as Determined by Strontium\n                    <sup>85<\/sup>"],"prefix":"10.1177","volume":"82","author":[{"suffix":"Jr.","given":"F. H.","family":"Linthicum","sequence":"first","affiliation":[{"name":"Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard P.","family":"House","sequence":"additional","affiliation":[{"name":"Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean R.","family":"Althaus","sequence":"additional","affiliation":[{"name":"Oakland, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1973,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020383026"},{"key":"e_1_2_1_3_2","first-page":"566","article-title":"Otosclerosis: A new challenge to roentgenology","volume":"94","author":"Valvassori GE","unstructured":"Valvassori GE: Otosclerosis: A new challenge to roentgenology. Amer J Roentgen 94: 566\u2013575.","journal-title":"Amer J Roentgen"},{"key":"e_1_2_1_4_2","first-page":"356","article-title":"Multiple Spongiosierung der Labyrinthkapsel als Sectionsbefund bei einem Fall von progressiver Schwerhorigkeit","volume":"34","author":"Siebenmann F","year":"1899","unstructured":"Siebenmann F: Multiple Spongiosierung der Labyrinthkapsel als Sectionsbefund bei einem Fall von progressiver Schwerhorigkeit. Z Ohrenheilk 34: 356\u2013374, 1899.","journal-title":"Z Ohrenheilk"},{"key":"e_1_2_1_5_2","article-title":"Labyrinthine otosclerosis","author":"Kelemen G","year":"1969","unstructured":"Kelemen G, Linthicum FHJr: Labyrinthine otosclerosis. Acta Oto-laryng, Suppl 253, 1969.","journal-title":"Acta Oto-laryng"},{"key":"e_1_2_1_6_2","first-page":"512","article-title":"Correlation of sensorineural hearing impairment and otosclerosis","volume":"75","author":"Linthicum FH","year":"1966","unstructured":"Linthicum FHJr: Correlation of sensorineural hearing impairment and otosclerosis. Ann Otol 75: 512, 1966.","journal-title":"Ann Otol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020343022"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770080854011"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"Otosclerosis: An electron microscopic and cytochemical study","volume":"272","author":"Chevance LG","year":"1970","unstructured":"Chevance LG, Bretlau P, J\u00f8rgensen MB, : Otosclerosis: An electron microscopic and cytochemical study. Acta Oto-laryng (Suppl) 272: 1\u201327, 1970.","journal-title":"Acta Oto-laryng"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540751012"},{"key":"e_1_2_1_11_2","first-page":"485","volume-title":"Experiments in Hearing","author":"von B\u00e9k\u00e9sy Georg","year":"1960","unstructured":"von B\u00e9k\u00e9sy Georg: Experiments in Hearing, New York, McGraw Hill, 1960 pp 485\u2013534."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1121\/1.1908025"},{"key":"e_1_2_1_13_2","first-page":"593","volume-title":"Radioactive Pharmaceuticals","author":"Andrews GA","year":"1966","unstructured":"Andrews GA, Knisely RM, Wagner HN, (eds): Radioactive Pharmaceuticals, U.S. Atomic Energy Commission\/Division of Technical Information, April 1966, Ch 32, pp 593\u2013601."},{"key":"e_1_2_1_14_2","first-page":"593","volume-title":"Nuclear Medicine","author":"Blahd WH","unstructured":"Blahd WH: Nuclear Medicine, 2nd Ed. New York, McGraw-Hill, pp 593\u2013601.","edition":"2"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947308200417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348947308200417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:26:47Z","timestamp":1777375607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348947308200417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,7]]}},"alternative-id":["10.1177\/000348947308200417"],"URL":"https:\/\/doi.org\/10.1177\/000348947308200417","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,7]]}}}