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Untreated pallid mice which showed head-tilting, circling and ataxia also had swimming difficulty. In these animals, the otolith defects were the only consistent findings. With one exception, no pronounced anomalies were found in the sensory epithelium, nerve fibers and ganglion cells. Only a few vestibular melanocytes, in which the melanin granules failed to fully mature, were observed in the pallid mouse. Melanization in vestibular melanocytes appeared to be improved by Mn-supplementation. The genetic basis for involvement of Mn in otolith development was discussed. This animal model provides opportunities for basic research concerning the possible prevention of genetic disorders involving the inner ear.<\/jats:p>","DOI":"10.1177\/000348947408300502","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:29:51Z","timestamp":1412346591000},"page":"565-581","source":"Crossref","is-referenced-by-count":22,"title":["Influence of Manganese on Genetically Defective Otolith"],"prefix":"10.1177","volume":"83","author":[{"given":"David J.","family":"Lim","sequence":"first","affiliation":[{"name":"Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence C.","family":"Erway","sequence":"additional","affiliation":[{"name":"Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1974,9,1]]},"reference":[{"key":"bibr1-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1951.sp004632"},{"key":"bibr2-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982950"},{"key":"bibr3-000348947408300502","first-page":"230","volume":"3","author":"Lyon MF","year":"1955","journal-title":"J Embryol Exp Morphol"},{"key":"bibr4-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3730.1766"},{"key":"bibr5-000348947408300502","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/genetics\/67.1.97","volume":"67","author":"Erway LC","year":"1971","journal-title":"Genetics"},{"key":"bibr6-000348947408300502","first-page":"34","volume":"37","author":"Lane PW","year":"1967","journal-title":"Mouse News Letter"},{"key":"bibr7-000348947408300502","first-page":"38","volume":"32","author":"Lyon MF","year":"1965","journal-title":"Mouse News Letter"},{"key":"bibr8-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300002007"},{"key":"bibr9-000348947408300502","first-page":"37","volume":"19","author":"Kelly EM","year":"1958","journal-title":"Mouse News Letter"},{"key":"bibr10-000348947408300502","first-page":"38","volume":"32","author":"Lyon MF","year":"1965","journal-title":"Mouse News Letter"},{"issue":"69","key":"bibr11-000348947408300502","volume-title":"Genetic and nutritional interactions of some pigment mutants, manganese metabolism and otolith development","author":"Erway LC","year":"1968"},{"key":"bibr12-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108366"},{"key":"bibr13-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/100.6.643"},{"key":"bibr14-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/91.4.453"},{"key":"bibr15-000348947408300502","first-page":"193","volume":"27","author":"Hurley LS","year":"1968","journal-title":"Fed Proc"},{"key":"bibr16-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1007\/BF02144891"},{"key":"bibr17-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90178-9"},{"key":"bibr18-000348947408300502","doi-asserted-by":"publisher","DOI":"10.1111\/j.2164-0947.1951.tb01007.x"},{"key":"bibr19-000348947408300502","first-page":"705","volume":"45","author":"Lim DJ","year":"1974","journal-title":"Aerosp Med"},{"key":"bibr20-000348947408300502","doi-asserted-by":"publisher","DOI":"10.3109\/00016485509118139"},{"key":"bibr21-000348947408300502","unstructured":"Henle: Quoted by Rudinger in Stricker's Manual of Human and Comparative Histology, vol 3. 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